The following list is of important municipalities in the Castile and León, an autonomous community of Spain:
The following links are to lists which are more detailed province-specific, and all municipalities in a given province are ranked by population.
| Rank | Name | Population (2020)[1] | |
|---|---|---|---|
| 1 | Valladolid | 299,265 | |
| 2 | Burgos | 176,418 | |
| 3 | Salamanca | 144,825 | |
| 4 | León | 124,028 | |
| 5 | Palencia | 78,144 | |
| 6 | Ponferrada | 64,509 | |
| 7 | Zamora | 60,988 | |
| 8 | Ávila | 58,369 | |
| 9 | Segovia | 52,057 | |
| 10 | Soria | 39,821 | |
| 11 | Miranda de Ebro | 35,760 | |
| 12 | Aranda de Duero | 33,187 | |
| 13 | San Andrés del Rabanedo | 30,549 | |
| 14 | Laguna de Duero | 22,765 | |
| 15 | Arroyo de la Encomienda | 20,537 | |
| 16 | Medina del Campo | 20,416 | |
| 17 | Villaquilambre | 18,684 | |
| 18 | Benavente | 17,787 | |
| 19 | Santa Marta de Tormes | 14,730 | |
| 20 | Béjar | 12,559 | |
| 21 | Ciudad Rodrigo | 12,261 | |
| 22 | Astorga | 10,741 | |
| 23 | La Bañeza | 10,290 | |
| 24 | Cuéllar | 9,659 | |
| 25 | El Espinar | 9,086 | |
| 26 | Cistérniga | 9,016 | |
| 27 | Tordesillas | 8,745 | |
| 28 | Toro | 8,665 | |
| 29 | Tudela de Duero | 8,620 | |
| 30 | Bembibre | 8,598 |