List of intestinal epithelial differentiation genes explained

Table of genes implicated in development and differentiation of the intestinal epithelium[1]

The table listed below is a running comprehensive list of all intestinal differential genes that have been reported in the literature. The PMID is the pubmed identification number of the papers that support the summarized information in the table corresponding to each row.

Official Common Function/phenotype PMID
15716339 [2]
Math1, HATH1Commitment to secretory lineage 20691176[3] 17570220[4] 11739954 [5]
PRDM1Postnatal epithelial maturation; suckling/weaning transition 21878906 [6] 21670299 [7]
Involved in terminal differentiation of secretory cells 17678919 [8]
Mtgr1 Required for maintenance of secretory lineage 16227606 [9]
E-cadherin Required for maturation/localization of Paneth and goblet cells 21179475 [10]
Cdx1 Induced expression promoted enterocyte differentiation in IEC6 cells 19059241 [11] 10579974 [12]
Cdx2 Involves in epithelial cell maturation as well as goblet and Paneth cell differentiation. Required for the small intestinal identity during development. In IEC-6 cells, conditional expression induced enterocyte and goblet like cells 21081128[13] 19386267[14] 8552090 [15]
Catenin, beta Paneth cell differentiation. Essential for stem cell/crypt maintenance. Villus and crypt morphogenesis with Tcf3 via c-Myc 18948094[16] 17785439[17] 17681174 [18]
Functions as a cis acting element and required for goblet cell differentiation in the Notch inactive colonic epithelia. Notch ligand in intestine. Required for the maintenance of stem and progenitors 20170633[19] 21238454 [20]
Notch ligand in intestine. Required for the maintenance of stem and progenitors 21238454
ESE-1 Terminal differentiation of absorptive enterocytes 19801644 [21]
Localization of Paneth cells to crypt base 12408869 [22]
KGF 19326389 [23]
Paneth cell specification through beta-catenin/Tcf4 dependent and independent pathway. Significant reduction in Paneth cell in knockout mice. Involved in crypt development and stem cell expansion 19407216 [24]
HNF3A 19737569 [25]
FOXA2HNF3B 19737569
Required for Paneth cell maturation. Loss of Paneth cell genes after conditional deletion 15778706 [26]
Crif1 Essential Elf3 coactivator in differentiation of absorptive enterocytes 19801644
Regulates proximal-distal identity in the intestines 21262227 [27]
Required for proximal intestinal identity 16940177 [28] 18812176 [29]
Required for proper allocation of secretory lineage 16230531 [30]
Hes1 Commitment to absorptive lineage 10615124 [31]
HNF1-α Regulates terminal differentiation of enterocytes and secretory cells potentially by direct regulation of Atoh1 20133952 [32] 20388655 [33]
HNF1-β Regulates terminal differentiation of enterocytes and secretory cells potentially by direct regulation of Atoh1 20133952 20388655
14770182 [34]
GKLF 21070761[35] 12015290 [36]
GPR48 Promotes Paneth cell differentiation and crypt cell proliferation. Along with LGR5, acts as the receptor for R-Spondin, a WNT co-ligand that amplifies WNT signaling 21508962 [37] 21909076 [38]
GPR49 Premature paneth cell differentiation in fetal intestine. Intestinal stem cell marker. Along with LGR4, acts as the receptor for R-Spondin, a WNT co-ligand that amplifies WNT signaling 19394326 [39] 21727895 [40]
17484881 [41]
Suppress paneth cell differentiation independent of Notch and Wnt signaling pathways 19214660 [42]
20857481;[43] 20133952 [44]
Crypt loss upon conditional deletion in the adult 16954380 [45]
BETA2 Differentiation of Ngn3 enteroendocrine cells into CCK and secretin cells 18022152;[46] 15044355 [47]
NGN3, ATOH5Commitment to the enteroendocrine cell lineage 17706959;[48] 12456641 [49]
Nkx2.2 18022152
Regulates absorptive cells vs secretory cells 15959516;[50] 18274550 [51]
Regulates absorptive cells vs secretory cells 15959516; 18274550
20351171 [52]
Differentiation of GIP in enteroendocrine lineage 18022152; 10478839 [53]
IPF1 Overexpression causes differentiation of immature intestinal epithelia to enteroendocrine cells. Conditional deletion alters enterocyte and enteroendocrine gene expression 11408276;[54] 19808654 [55]
PPAR-δ/β Involves in Paneth cell maturation by modulating IHH expression 16890607 [56]
BRK 16782882 [57]
pRB Required for enterocyte terminal differentiation in small intestine 18981186 [58]
CBF1 Conversion of progenitors and differentiated cells into goblet cells by conditional deletion 15959515 [59]
REG4Marker for enteroendocrine cells

26287467 [60]

17698607;[61] 17681175 [62]
PDEFRegulates terminal differentiation of goblet cells and Paneth cells 19786015;[63] 19549527 [64]
LKB1 Required for normal differentiation of goblet and Paneth cells 19165340[65]
Tgf-βRII 17408644 [66]
19139088 [67]

Notes and References

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  4. Shroyer . N. F. . Helmrath . M. A. . Wang . V. Y. –C. . Antalffy . B. . Henning . S. J. . Zoghbi . H. Y. . 10.1053/j.gastro.2007.03.047 . Intestine-Specific Ablation of Mouse atonal homolog 1 (Math1) Reveals a Role in Cellular Homeostasis . Gastroenterology . 132 . 7 . 2478–2488 . 2007 . 17570220. free .
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