This is a list of active airlines (2019) which have an Air Operator Certificate issued by the Civil Aviation Authority of Paraguay.
| Airline | Image | IATA | ICAO | Callsign | Founded | Notes | |
|---|---|---|---|---|---|---|---|
| Delcar Express | 2007 | ||||||
| Air Europa Paraguay | 2022 | ||||||
| LATAM Paraguay | PZ | LAP | PARAGUAYA | 2016 | |||
| Paranair | ZP | AZP | GUARANI | 2018 | |||
| Sol del Paraguay | PI | SGU | SOLPARAGUAYO | 2010 | |||
| Transporte Aéreo Guaraní | TAGUA | 2014 | |||||