This is a list of cities (communes) in French Guiana:
| Largest communes in French Guiana | |||||
| Rank | Communes | Population | Arrondissement | ||
| 1999 | 2009 | ||||
| 1. | Cayenne | 50,594 | 71,087 | Cayenne | |
| 2. | 18,032 | 34,533 | Cayenne | ||
| 3. | 19,211 | 28,944 | Saint-Laurent-du-Maroni | ||
| 4. | 19,171 | 28,416 | Cayenne | ||
| 5. | 15,555 | 22,125 | Cayenne | ||
| 6. | 5 050 | 13 019 | Cayenne | ||
| 7. | 3 710 | 8 364 | Saint-Laurent-du-Maroni | ||
| 8. | 5 445 | 6 271 | Saint-Laurent-du-Maroni | ||
| 9. | 3 628 | 5 789 | Saint-Laurent-du-Maroni | ||
| 10. | 2 862 | 4 966 | Saint-Laurent-du-Maroni | ||
| 11. | 2 783 | 3 400 | Cayenne | ||
| 12. | 2 153 | 3 276 | Cayenne | ||
| 13. | 1 791 | 2 621 | Cayenne | ||
| 14. | 1 430 | 1 579 | Cayenne | ||
| 15. | 1 032 | 1 530 | Cayenne | ||
| 16. | 887 | 1 344 | Saint-Laurent-du-Maroni | ||