List of breast cancer cell lines explained

Scientists study the behaviour of isolated cells grown in the laboratory for insights into how cells function in the body in health and disease. Experiments using cell culture are used for developing new diagnostic tests and new treatments for diseases.This is a list of major breast cancer cell lines that are primarily used in breast cancer research.

List of cell lines

Cell line	Primary tumor	Origin of cells	Estrogen receptors	Progesterone receptors	ERBB2 amplification		Tumorigenic in mice	Reference	External links
600MPE	Invasive ductal carcinoma		+	–		–		^[1]	Cellosaurus
	Invasive ductal carcinoma		Yes	Yes	No	-	-	^[2]	Cellosaurus
AU565	Adenocarcinoma		–	–	+	–			Cellosaurus
	Invasive ductal carcinoma		No	No	No	Yes	Yes	^[3]	Cellosaurus
BT-474	Invasive ductal carcinoma		Yes	Yes	Yes	Yes	Yes	^[4]	Cellosaurus
BT-483	Invasive ductal carcinoma		+	+		–			Cellosaurus
BT-549	Invasive ductal carcinoma		–	–		+			Cellosaurus
Evsa-T	Invasive ductal carcinoma, mucin-producing, signet-ring type	Metastasis (ascites)	No	Yes	?	Yes	?	^[5]	Cellosaurus
Hs578T	Invasive ductal carcinoma		No	No	No	Yes	No	^[6]	Cellosaurus
	Invasive ductal carcinoma	Metastasis (pleural effusion)	Yes	Yes^[7]	No	No (wild-type)	Yes (with estrogen supplementation)	^[8]	Cellosaurus
MDA-MB-231	Adenocarcinoma	Metastasis (pleural effusion)	No	No	No	Yes	Yes	^[9]	Cellosaurus
	Invasive ductal carcinoma	Metastasis (pleural effusion)	No	No	Yes	Yes	No	^[10]	Cellosaurus
	Invasive ductal carcinoma	Metastasis (pleural effusion)	Yes	Yes	No	Yes	Yes (with estrogen supplementation)	^[11]	Cellosaurus
	Invasive ductal carcinoma							^[12]	Cellosaurus

Notes and References

Neve RM, etal . A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes . Cancer Cell . 10 . 6 . 515–527 . 2006 . 17157791 . 2730521 . 10.1016/j.ccr.2006.10.008 .
Al-Shammari A, Alshami M, Umran M, Almukhtar A, Yaseen N, Raad K, Hussien A . Establishment and characterization of a receptor-negative, hormone-nonresponsive breast cancer cell line from an Iraqi patient . Breast Cancer: Targets and Therapy . 2015 . 7 . 223–230 . 2015 . 26300657 . 10.2147/BCTT.S74509. 4536763 . free .
Lasfargues EY, Ozzello L . Cultivation of human breast carcinomas . Journal of the National Cancer Institute . 21 . 6 . 1131–1147 . 1958 . 13611537 .
Lasfargues EY, Coutinho WG, Redfield ES . Isolation of two human tumor epithelial cell lines from solid breast carcinomas . Journal of the National Cancer Institute . 61 . 4 . 967–978 . 1978 . 212572 . 10.1093/jnci/61.4.967 .
Borras M, Lacroix M . Estrogen receptor-negative/progesterone receptor-positive Evsa-T mammary tumor cells: a model for assessing the biological property of this peculiar phenotype of breast cancers . Cancer Letters . 120 . 1 . 23–30 . 1997 . 9570382 . 10.1016/S0304-3835(97)00285-1 .
Hackett AJ, Smith HS, Springer EL, Owens RB, Nelson-Rees WA, Riggs JL, Gardner MB . Two syngeneic cell lines from human breast tissue: the aneuploid mammary epithelial (Hs578T) and the diploid myoepithelial (Hs578Bst) cell lines . Journal of the National Cancer Institute . 58 . 6 . 1795–1806 . 1977 . 864756 . 10.1093/jnci/58.6.1795 .
Kao. Jessica. Salari. Keyan. Bocanegra. Melanie. Choi. Yoon-La. Girard. Luc. Gandhi. Jeet. Kwei. Kevin A.. Hernandez-Boussard. Tina. Wang. Pei. 2009-07-03. Molecular Profiling of Breast Cancer Cell Lines Defines Relevant Tumor Models and Provides a Resource for Cancer Gene Discovery. PLOS ONE. 4. 7. e6146. 10.1371/journal.pone.0006146. 19582160. 2702084. 1932-6203. 2009PLoSO...4.6146K. free.
Soule HD, Vazguez J, Long A, Albert S, Brennan M . A human cell line from a pleural effusion derived from a breast carcinoma . Journal of the National Cancer Institute . 51 . 5 . 1409–1416 . 1973 . 4357757 . 10.1093/jnci/51.5.1409 .
Cailleau R, Young R, Olivé M, ((Reeves WJ Jr)) . Breast tumor cell lines from pleural effusions . Journal of the National Cancer Institute . 53 . 3 . 661–674 . 1974 . 4412247 . 10.1093/jnci/53.3.661 . 7364228 .
Engel LW, Young NA . Human breast carcinoma cells in continuous culture: a review . . 38 . 11 Pt 2 . 4327–4339 . 1978 . 212193 .
Keydar I, Chen L, Karby S, Weiss FR, Delarea J, Radu M, Chaitcik S, Brenner HJ . Establishment and characterization of a cell line of human breast carcinoma origin . European Journal of Cancer . 15 . 5 . 659–670 . 1979 . 228940 . 10.1016/0014-2964(79)90139-7.
Dorssers . LC . van Agthoven . T . Genetic mechanisms of estrogen-independence in breast cancer. . Pathology, Research and Practice . July 1996 . 192 . 7 . 743–51 . 10.1016/S0344-0338(96)80096-3 . 8880875 .