These hits topped the Ultratop 50 in 2008.[1]
| Issue Date | Artist | Song | |
|---|---|---|---|
| January 5 | Don't Stop the Music | ||
| January 12 | |||
| January 19 | |||
| January 26 | |||
| February 2 | |||
| February 9 | Bleeding Love | ||
| February 16 | |||
| February 23 | |||
| March 1 | |||
| March 8 | |||
| March 15 | |||
| March 22 | |||
| March 29 | O julissi 1 | ||
| April 5 | |||
| April 12 | Een ster (A Star) | ||
| April 19 | Al duurt de nacht tot morgenvroeg | ||
| April 26 | 4Minutes | ||
| May 3 | |||
| May 10 | |||
| May 17 | |||
| May 24 | |||
| May 31 | |||
| June 7 | American Boy | ||
| June 14 | |||
| June 21 | No Stress | ||
| June 28 | This Is the Life | ||
| July 5 | |||
| July 12 | |||
| July 19 | |||
| July 26 | |||
| August 2 | |||
| August 9 | |||
| August 16 | |||
| August 23 | |||
| August 30 | |||
| September 6 | |||
| September 13 | I Kissed a Girl | ||
| September 20 | |||
| September 27 | |||
| October 4 | |||
| October 11 | Disturbia | ||
| October 18 | Katy Perry | I Kissed a Girl | |
| October 25 | Ayo Technology | ||
| November 1 | |||
| November 8 | Infinity 2008 | ||
| November 15 | |||
| November 22 | |||
| November 29 | |||
| December 6 | |||
| December 13 | |||
| December 20 | Womanizer | ||
| December 27 | Home |