These are the singles that reached number one on the Top 100 Singles chart in 1985 as published by Cashbox magazine.
| Indicates best-performing single of 1985 |
| Issue date | Song | Artist | |
|---|---|---|---|
| January 5 | "Like a Virgin" | Madonna | |
| January 12 | |||
| January 19 | |||
| January 26 | |||
| February 2 | "I Want to Know What Love Is" | Foreigner | |
| February 9 | "Easy Lover" | Philip Bailey and Phil Collins | |
| February 16 | "Careless Whisper" | Wham! featuring George Michael | |
| February 23 | |||
| March 2 | |||
| March 9 | "Can't Fight This Feeling" | REO Speedwagon | |
| March 16 | |||
| March 23 | |||
| March 30 | "Material Girl" | Madonna | |
| April 6 | "One More Night" | Phil Collins | |
| April 13 | bgcolor=#FFFF99 rowspan="5" | "We Are the World" | USA for Africa |
| April 20 | |||
| April 27 | |||
| May 4 | |||
| May 11 | |||
| May 18 | "Don't You (Forget About Me)" | Simple Minds | |
| May 25 | |||
| June 1 | "Everything She Wants" | Wham! | |
| June 8 | "Everybody Wants to Rule the World" | Tears for Fears | |
| June 15 | |||
| June 22 | "Heaven" | Bryan Adams | |
| June 29 | "Sussudio" | Phil Collins | |
| July 6 | |||
| July 13 | "A View to a Kill" | Duran Duran | |
| July 20 | "Raspberry Beret" | Prince and The Revolution | |
| July 27 | "Everytime You Go Away" | Paul Young | |
| August 3 | |||
| August 10 | "Shout" | Tears for Fears | |
| August 17 | |||
| August 24 | "The Power of Love" | Huey Lewis and the News | |
| August 31 | |||
| September 7 | "St. Elmo's Fire (Man in Motion)" | John Parr | |
| September 14 | |||
| September 21 | "Money for Nothing" | Dire Straits | |
| September 28 | |||
| October 5 | |||
| October 12 | |||
| October 19 | "Take On Me" | a-ha | |
| October 26 | |||
| November 2 | "Part-Time Lover" | Stevie Wonder | |
| November 9 | "Miami Vice Theme" | Jan Hammer | |
| November 16 | "We Built This City" | Starship | |
| November 23 | |||
| November 30 | "Separate Lives" | Phil Collins and Marilyn Martin | |
| December 7 | "Broken Wings" | Mr. Mister | |
| December 14 | |||
| December 21 | "Say You, Say Me" | Lionel Richie | |
| December 28 |