LZTS1 explained

Leucine zipper putative tumor suppressor 1 is a protein that, in humans, is encoded by the LZTS1 gene.^{[1] [2] [3]}

In melanocytic cells LZTS1 gene expression may be regulated by MITF.^[4]

Interactions

LZTS1 has been shown to interact with EEF1G.^[5]

Further reading

• Ono K, Uzawa K, Nakatsuru M, Shiiba M, Mochida Y, Tada A, Bukawa H, Miyakawa A, Yokoe H, Tanzawa H . Down-regulation of FEZ1/LZTS1 gene with frequent loss of heterozygosity in oral squamous cell carcinomas. . Int. J. Oncol. . 23 . 2 . 297–302 . 2004 . 12851677 . 10.3892/ijo.23.2.297 .
• Hawkins GA, Mychaleckyj JC, Zheng SL, Faith DA, Kelly B, Isaacs SD, Wiley KE, Chang BL, Ewing CM, Bujnovszky P, Bleecker ER, Walsh PC, Meyers DA, Isaacs WB, Xu J . Germline sequence variants of the LZTS1 gene are associated with prostate cancer risk. . Cancer Genet. Cytogenet. . 137 . 1 . 1–7 . 2002 . 12377406 . 10.1016/S0165-4608(02)00549-6 .
• Ishii H, Vecchione A, Murakumo Y, Baldassarre G, Numata S, Trapasso F, Alder H, Baffa R, Croce CM . FEZ1/LZTS1 gene at 8p22 suppresses cancer cell growth and regulates mitosis. . Proc. Natl. Acad. Sci. U.S.A. . 98 . 18 . 10374–9 . 2001 . 11504921 . 56968 . 10.1073/pnas.181222898 . free . 2001PNAS...9810374I .
• Cabeza-Arvelaiz Y, Sepulveda JL, Lebovitz RM, Thompson TC, Chinault AC . Functional identification of LZTS1 as a candidate prostate tumor suppressor gene on human chromosome 8p22. . Oncogene . 20 . 31 . 4169–79 . 2001 . 11464283 . 10.1038/sj.onc.1204539 . 38760860 .

Notes and References

1. Ishii H, Baffa R, Numata SI, Murakumo Y, Rattan S, Inoue H, Mori M, Fidanza V, Alder H, Croce CM . The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors . Proc Natl Acad Sci U S A . 96 . 7 . 3928–33 . May 1999 . 10097140 . 22397 . 10.1073/pnas.96.7.3928 . free . 1999PNAS...96.3928I .
2. Vecchione A, Baldassarre G, Ishii H, Nicoloso MS, Belletti B, Petrocca F, Zanesi N, Fong LY, Battista S, Guarnieri D, Baffa R, Alder H, Farber JL, Donovan PJ, Croce CM . Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development . Cancer Cell . 11 . 3 . 275–89 . Mar 2007 . 17349584 . 1987708 . 10.1016/j.ccr.2007.01.014 .
3. Web site: Entrez Gene: LZTS1 leucine zipper, putative tumor suppressor 1.
4. Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E . Novel MITF targets identified using a two-step DNA microarray strategy . Pigment Cell Melanoma Res. . 21 . 6 . 665–76 . 2008 . 19067971 . 10.1111/j.1755-148X.2008.00505.x . 24698373 . free .
5. Ishii H, Vecchione A, Murakumo Y, Baldassarre G, Numata S, Trapasso F, Alder H, Baffa R, Croce CM . FEZ1/LZTS1 gene at 8p22 suppresses cancer cell growth and regulates mitosis . . 98 . 18 . 10374–9 . Aug 2001 . 11504921 . 56968 . 10.1073/pnas.181222898 . free . 2001PNAS...9810374I .