LY-2365109 explained

LY-2365109 is a glycine reuptake inhibitor. It is able to inhibit the type 1 glycine transporter.[1] This inhibition increases extracellular levels of glycine. LY-2365109 has been shown to increase the seizure threshold in mice, meaning that this drug has potential as an anticonvulsant.[2]

Notes and References

  1. Zhang . Jichun . Wu . Jin . Toyohara . Jun . Fujita . Yuko . Chen . Hongxian . Hashimoto . Kenji . 2011 . Pharmacological characterization of [³H]CHIBA-3007 binding to glycine transporter 1 in the rat brain . PLOS ONE . 6 . 6 . e21322 . 10.1371/journal.pone.0021322 . free . 1932-6203 . 3121759 . 21731704. 2011PLoSO...621322Z .
  2. Shen . Hai-Ying . van Vliet . Erwin A. . Bright . Kerry-Ann . Hanthorn . Marissa . Lytle . Nikki K. . Gorter . Jan . Aronica . Eleonora . Boison . Detlev . December 2015 . Glycine transporter 1 is a target for the treatment of epilepsy . Neuropharmacology . 99 . 554–565 . 10.1016/j.neuropharm.2015.08.031 . 1873-7064 . 4655139 . 26302655.

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