LTN1 explained

Listerin E3 ubiquitin protein ligase 1 (LTN1), otherwise known as listerin, is a protein that in humans is encoded by the LTN1 gene.^[1]

Function

Like most RING finger proteins, listerin functions as an E3 ubiquitin ligase.^[2] Listerin is a component of the ribosome quality control complex.^{[3] [4]}

Further reading

• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR . Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score . Molecular Medicine . 16 . 7–8 . 247–53 . 2010 . 20379614 . 2896464 . 10.2119/molmed.2009.00159 .
• Shao S, Brown A, Santhanam B, Hegde RS . Structure and assembly pathway of the ribosome quality control complex . Molecular Cell . 57 . 3 . 433–44 . February 2015 . 25578875 . 4321881 . 10.1016/j.molcel.2014.12.015 .

Notes and References

1. Web site: Entrez Gene: Listerin E3 ubiquitin protein ligase 1 .
2. Chu J, Hong NA, Masuda CA, Jenkins BV, Nelms KA, Goodnow CC, Glynne RJ, Wu H, Masliah E, Joazeiro CA, Kay SA . A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration . Proceedings of the National Academy of Sciences of the United States of America . 106 . 7 . 2097–103 . February 2009 . 19196968 . 10.1073/pnas.0812819106 . 2650114 . free .
3. Shao S, Brown A, Santhanam B, Hegde RS . Structure and assembly pathway of the ribosome quality control complex . Molecular Cell . 57 . 3 . 433–44 . February 2015 . 25578875 . 10.1016/j.molcel.2014.12.015 . 4321881 .
4. Shao S, von der Malsburg K, Hegde RS . Listerin-dependent nascent protein ubiquitination relies on ribosome subunit dissociation . Molecular Cell . 50 . 5 . 637–48 . June 2013 . 23685075 . 10.1016/j.molcel.2013.04.015 . 3719020 .