LTBP3 explained

Latent-transforming growth factor beta-binding protein 3 is a protein that in humans is encoded by the LTBP3 gene.^{[1] [2]}

Further reading

• Saharinen J, Hyytiäinen M, Taipale J, Keski-Oja J . Latent transforming growth factor-beta binding proteins (LTBPs)--structural extracellular matrix proteins for targeting TGF-beta action. . Cytokine Growth Factor Rev. . 10 . 2 . 99–117 . 2000 . 10743502 . 10.1016/S1359-6101(99)00010-6 .
• Oklü R, Hesketh R . The latent transforming growth factor beta binding protein (LTBP) family . Biochem. J. . 352 Pt 3 . Pt 3. 601–10 . 2001 . 11104663 . 10.1042/0264-6021:3520601. 1221494 .
• Morén A, Olofsson A, Stenman G, etal . Identification and characterization of LTBP-2, a novel latent transforming growth factor-beta-binding protein . J. Biol. Chem. . 269 . 51 . 32469–78 . 1995 . 10.1016/S0021-9258(18)31659-4 . 7798248 . free .
• Michel K, Roth S, Trautwein C, etal . Analysis of the expression pattern of the latent transforming growth factor beta binding protein isoforms in normal and diseased human liver reveals a new splice variant missing the proteinase-sensitive hinge region . Hepatology . 27 . 6 . 1592–9 . 1998 . 9620332 . 10.1002/hep.510270619 . 41314097 . free .
• Saharinen J, Keski-Oja J . Specific Sequence Motif of 8-Cys Repeats of TGF-β Binding Proteins, LTBPs, Creates a Hydrophobic Interaction Surface for Binding of Small Latent TGF-β . Mol. Biol. Cell . 11 . 8 . 2691–704 . 2000 . 10930463 . 10.1091/mbc.11.8.2691. 14949 .
• Brooke JS, Cha JH, Eidels L . Latent transforming growth factor β-binding protein-3 and fibulin-1C interact with the extracellular domain of the heparin-binding EGF-like growth factor precursor . BMC Cell Biol. . 3. 2 . 2002 . 11846885 . 10.1186/1471-2121-3-2 . 65547 . free .
• Chen Y, Dabovic B, Annes JP, Rifkin DB . Latent TGF-beta binding protein-3 (LTBP-3) requires binding to TGF-beta for secretion . FEBS Lett. . 517 . 1–3 . 277–80 . 2002 . 12062452 . 10.1016/S0014-5793(02)02648-0 . 83982805 . free . 2002FEBSL.517..277C .
• Penttinen C, Saharinen J, Weikkolainen K, etal . Secretion of human latent TGF-beta-binding protein-3 (LTBP-3) is dependent on co-expression of TGF-beta . J. Cell Sci. . 115 . Pt 17 . 3457–68 . 2003 . 10.1242/jcs.115.17.3457 . 12154076 . free .
• Ludbrook SB, Barry ST, Delves CJ, Horgan CM . The integrin alphavbeta3 is a receptor for the latency-associated peptides of transforming growth factors beta1 and beta3 . Biochem. J. . 369 . Pt 2 . 311–8 . 2003 . 12358597 . 10.1042/BJ20020809 . 1223078 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Colland F, Jacq X, Trouplin V, etal . Functional Proteomics Mapping of a Human Signaling Pathway . Genome Res. . 14 . 7 . 1324–32 . 2004 . 15231748 . 10.1101/gr.2334104 . 442148 .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Koli K, Hyytiäinen M, Ryynänen MJ, Keski-Oja J . Sequential deposition of latent TGF-beta binding proteins (LTBPs) during formation of the extracellular matrix in human lung fibroblasts . Exp. Cell Res. . 310 . 2 . 370–82 . 2005 . 16157329 . 10.1016/j.yexcr.2005.08.008 .
• Kantola AK, Keski-Oja J, Koli K . Induction of human LTBP-3 promoter activity by TGF-beta1 is mediated by Smad3/4 and AP-1 binding elements . Gene . 363 . 142–50 . 2006 . 16223572 . 10.1016/j.gene.2005.07.042 .

Notes and References

1. Li X, Yin W, Perez-Jurado L, Bonadio J, Francke U . Mapping of human and murine genes for latent TGF-beta binding protein-2 (LTBP2) . Mamm Genome . 6 . 1 . 42–5 . May 1995 . 7719025 . 10.1007/BF00350892 . 2027.42/47013 . 32672633 . free .
2. Web site: Entrez Gene: LTBP3 latent transforming growth factor beta binding protein 3.