LTBP2 explained

Latent-transforming growth factor beta-binding protein 2 is a protein that in humans is encoded by the LTBP2 gene.^{[1] [2]}

The protein encoded by this gene belongs to the family of latent transforming growth factor (TGF)-beta binding proteins (LTBP), which are extracellular matrix proteins with multi-domain structure. This protein is the largest member of the LTBP family possessing unique regions and with most similarity to the fibrillins.

It has thus been suggested that it may have multiple functions: as a member of the TGF-beta latent complex, as a structural component of microfibrils, and a role in cell adhesion.

Further reading

• Chambaz EM, Souchelnitskiy S, Pellerin S, etal . Transforming growth factors-beta s: a multifunctional cytokine family. Implication in the regulation of adrenocortical cell endocrine functions . Horm. Res. . 45 . 3–5 . 222–6 . 1996 . 8964588 . 10.1159/000184792 .
• Munger JS, Harpel JG, Gleizes PE, etal . Latent transforming growth factor-beta: structural features and mechanisms of activation . Kidney Int. . 51 . 5 . 1376–82 . 1997 . 9150447 . 10.1038/ki.1997.188 . free .
• Book: Taipale J, Saharinen J, Keski-Oja J . Extracellular matrix-associated transforming growth factor-beta: role in cancer cell growth and invasion . Adv. Cancer Res. . 75 . 87–134 . 1998 . 9709808 . 10.1016/S0065-230X(08)60740-X . Extracellular Matrix-Associated Transforming Growth Factor-β: Role in Cancer Cell Growth and Invasion . Advances in Cancer Research . 978-0-12-006675-9 .
• Saharinen J, Hyytiäinen M, Taipale J, Keski-Oja J . Latent transforming growth factor-beta binding proteins (LTBPs)--structural extracellular matrix proteins for targeting TGF-beta action . Cytokine Growth Factor Rev. . 10 . 2 . 99–117 . 2000 . 10743502 . 10.1016/S1359-6101(99)00010-6 .
• Oklü R, Hesketh R . The latent transforming growth factor beta binding protein (LTBP) family . Biochem. J. . 352 Pt 3 . 3. 601–10 . 2001 . 11104663 . 10.1042/0264-6021:3520601. 1221494 .
• Li X, Yin W, Pérez-Jurado L, etal . Mapping of human and murine genes for latent TGF-beta binding protein-2 (LTBP2) . Mamm. Genome . 6 . 1 . 42–5 . 1995 . 7719025 . 10.1007/BF00350892 . 2027.42/47013 . 32672633 . free .
• Bashir MM, Han MD, Abrams WR, etal . Analysis of the human gene encoding latent transforming growth factor-beta-binding protein-2 . Int. J. Biochem. Cell Biol. . 28 . 5 . 531–42 . 1996 . 8697098 . 10.1016/1357-2725(95)00167-0 .
• Hyytiäinen M, Taipale J, Heldin CH, Keski-Oja J . Recombinant latent transforming growth factor beta-binding protein 2 assembles to fibroblast extracellular matrix and is susceptible to proteolytic processing and release . J. Biol. Chem. . 273 . 32 . 20669–76 . 1998 . 9685426 . 10.1074/jbc.273.32.20669 . free .
• Saharinen J, Keski-Oja J . Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta . Mol. Biol. Cell . 11 . 8 . 2691–704 . 2000 . 10930463 . 10.1091/mbc.11.8.2691. 14949 .
• Wu X, Blanck A, Norstedt G, etal . Identification of genes with higher expression in human uterine leiomyomas than in the corresponding myometrium . Mol. Hum. Reprod. . 8 . 3 . 246–54 . 2002 . 11870232 . 10.1093/molehr/8.3.246 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Heilig R, Eckenberg R, Petit JL, etal . The DNA sequence and analysis of human chromosome 14 . Nature . 421 . 6923 . 601–7 . 2003 . 12508121 . 10.1038/nature01348 . 2003Natur.421..601H . free .
• Vehviläinen P, Hyytiäinen M, Keski-Oja J . Latent transforming growth factor-beta-binding protein 2 is an adhesion protein for melanoma cells . J. Biol. Chem. . 278 . 27 . 24705–13 . 2003 . 12716902 . 10.1074/jbc.M212953200 . free .
• Hirani R, Hanssen E, Gibson MA . LTBP-2 specifically interacts with the amino-terminal region of fibrillin-1 and competes with LTBP-1 for binding to this microfibrillar protein . Matrix Biol. . 26 . 4 . 213–23 . 2007 . 17293099 . 10.1016/j.matbio.2006.12.006 . 10.1.1.328.5118 .

External links

• GeneReview/NCBI/NIH/UW entry on Primary Congenital Glaucoma

Notes and References

1. Moren A, Olofsson A, Stenman G, Sahlin P, Kanzaki T, Claesson-Welsh L, ten Dijke P, Miyazono K, Heldin CH . Identification and characterization of LTBP-2, a novel latent transforming growth factor-beta-binding protein . J Biol Chem . 269 . 51 . 32469–78 . Jan 1995 . 10.1016/S0021-9258(18)31659-4 . 7798248 . free .
2. Web site: Entrez Gene: LTBP2 latent transforming growth factor beta binding protein 2.