LNX1 explained
E3 ubiquitin-protein ligase LNX is an enzyme that in humans is encoded by the LNX1 gene.[1] [2] [3]
Interactions
LNX1 has been shown to interact with NAGK,[4] NUMB and PAFAH1B3.[4]
Further reading
- Dho SE, Jacob S, Wolting CD, French MB, Rohrschneider LR, McGlade CJ . The mammalian numb phosphotyrosine-binding domain. Characterization of binding specificity and identification of a novel PDZ domain-containing numb binding protein, LNX . The Journal of Biological Chemistry . 273 . 15 . 9179–87 . Apr 1998 . 9535908 . 10.1074/jbc.273.15.9179 . free .
- Rice DS, Northcutt GM, Kurschner C . The Lnx family proteins function as molecular scaffolds for Numb family proteins . Molecular and Cellular Neurosciences . 18 . 5 . 525–40 . Nov 2001 . 11922143 . 10.1006/mcne.2001.1024 . 6021682 .
- Sollerbrant K, Raschperger E, Mirza M, Engstrom U, Philipson L, Ljungdahl PO, Pettersson RF . The Coxsackievirus and adenovirus receptor (CAR) forms a complex with the PDZ domain-containing protein ligand-of-numb protein-X (LNX) . The Journal of Biological Chemistry . 278 . 9 . 7439–44 . Feb 2003 . 12468544 . 10.1074/jbc.M205927200 . free .
- Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A . The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment . Genome Research . 13 . 10 . 2265–70 . Oct 2003 . 12975309 . 403697 . 10.1101/gr.1293003 .
- Katoh M, Katoh M . Identification and characterization of PDZRN3 and PDZRN4 genes in silico . International Journal of Molecular Medicine . 13 . 4 . 607–13 . Apr 2004 . 15010864 . 10.3892/ijmm.13.4.607 .
- Armbruester V, Sauter M, Roemer K, Best B, Hahn S, Nty A, Schmid A, Philipp S, Mueller A, Mueller-Lantzsch N . Np9 protein of human endogenous retrovirus K interacts with ligand of numb protein X . Journal of Virology . 78 . 19 . 10310–9 . Oct 2004 . 15367597 . 516385 . 10.1128/JVI.78.19.10310-10319.2004 .
- Chen J, Xu J, Zhao W, Hu G, Cheng H, Kang Y, Xie Y, Lu Y . Characterization of human LNX, a novel ligand of Numb protein X that is downregulated in human gliomas . The International Journal of Biochemistry & Cell Biology . 37 . 11 . 2273–83 . Nov 2005 . 16002321 . 10.1016/j.biocel.2005.02.028 .
- Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration . Cell . 125 . 4 . 801–14 . May 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . 13709685 . free .
- Weiss A, Baumgartner M, Radziwill G, Dennler J, Moelling K . c-Src is a PDZ interaction partner and substrate of the E3 ubiquitin ligase Ligand-of-Numb protein X1 . FEBS Letters . 581 . 26 . 5131–6 . Oct 2007 . 17936276 . 10.1016/j.febslet.2007.09.062 . 43098921 . free .
Notes and References
- Xie Y, Zhao W, Wang W, Zhao S, Tang R, Ying K, Zhou Z, Mao Y . Identification of a human LNX protein containing multiple PDZ domains . Biochemical Genetics . 39 . 3–4 . 117–26 . Apr 2001 . 11521506 . 10.1023/A:1010269908398 . 9150813 .
- Nie J, McGill MA, Dermer M, Dho SE, Wolting CD, McGlade CJ . LNX functions as a RING type E3 ubiquitin ligase that targets the cell fate determinant Numb for ubiquitin-dependent degradation . The EMBO Journal . 21 . 1–2 . 93–102 . Jan 2002 . 11782429 . 125803 . 10.1093/emboj/21.1.93 .
- Web site: Entrez Gene: LNX1 ligand of numb-protein X 1.
- Huda Zoghbi . Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .