LMOD3 explained

Leiomodin-3 is a protein that in humans is encoded by the LMOD3 gene.^[1] Leiomodin-3 is especially present at the pointed end of muscle thin filaments.^[2]

Clinical significance

Dysfunction is associated with thin filament disorganisation and nemaline myopathy.

Further reading

• Lane HY, Liu YC, Huang CL, Chang YC, Wu PL, Lu CT, Chang WH . Risperidone-related weight gain: genetic and nongenetic predictors . Journal of Clinical Psychopharmacology . 26 . 2 . 128–34 . April 2006 . 16633140 . 10.1097/01.jcp.0000203196.65710.2b . 34821033 .
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S . The LIFEdb database in 2006 . Nucleic Acids Research . 34 . Database issue . D415-8 . January 2006 . 16381901 . 1347501 . 10.1093/nar/gkj139 .
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A . From ORFeome to biology: a functional genomics pipeline . Genome Research . 14 . 10B . 2136–44 . October 2004 . 15489336 . 528930 . 10.1101/gr.2576704 .
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S . Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing . EMBO Reports . 1 . 3 . 287–92 . September 2000 . 11256614 . 1083732 . 10.1093/embo-reports/kvd058 .
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A . Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs . Genome Research . 11 . 3 . 422–35 . March 2001 . 11230166 . 311072 . 10.1101/gr.GR1547R .
• Hartley JL, Temple GF, Brasch MA . DNA cloning using in vitro site-specific recombination . Genome Research . 10 . 11 . 1788–95 . November 2000 . 11076863 . 310948 . 10.1101/gr.143000 .

Notes and References

1. Web site: Entrez Gene: LMOD3 leiomodin 3 (fetal) .
2. Nowak KJ, Davis MR, Wallgren-Pettersson C, Lamont PJ, Laing NG . Clinical utility gene card for: Nemaline myopathy - update 2015 . European Journal of Human Genetics . 23 . 11 . 4–5 . November 2015 . 25712079 . 10.1038/ejhg.2015.12 . 4613474 .