LIN7C explained

Lin-7 homolog C is a protein that in humans is encoded by the LIN7C gene.^{[1] [2]}

Interactions

LIN7C has been shown to interact with:

• DLG1,
• KCNJ12, and
• KCNJ4.^{[3] [4]}

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Bécamel C, Alonso G, Galéotti N, Demey E, Jouin P, Ullmer C, Dumuis A, Bockaert J, Marin P . Synaptic multiprotein complexes associated with 5-HT(2C) receptors: a proteomic approach . EMBO J. . 21 . 10 . 2332–42 . 2002 . 12006486 . 126011 . 10.1093/emboj/21.10.2332 .
• Hori K, Konno D, Maruoka H, Sobue K . MALS is a binding partner of IRSp53 at cell-cell contacts . FEBS Lett. . 554 . 1–2 . 30–4 . 2003 . 14596909 . 10.1016/S0014-5793(03)01074-3 . 30329043 . free . 2003FEBSL.554...30H .
• Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA . A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels . J. Biol. Chem. . 279 . 18 . 19051–63 . 2004 . 14960569 . 10.1074/jbc.M400284200 . free .
• Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA . Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins . J. Biol. Chem. . 279 . 21 . 22331–46 . 2004 . 15024025 . 10.1074/jbc.M400285200 . free .
• Petrosky KY, Ou HD, Löhr F, Dötsch V, Lim WA . A general model for preferential hetero-oligomerization of LIN-2/7 domains: mechanism underlying directed assembly of supramolecular signaling complexes . J. Biol. Chem. . 280 . 46 . 38528–36 . 2006 . 16147993 . 10.1074/jbc.M506536200 . free .
• Mendes CC, Gomes DA, Thompson M, Souto NC, Goes TS, Goes AM, Rodrigues MA, Gomez MV, Nathanson MH, Leite MF . The type III inositol 1,4,5-trisphosphate receptor preferentially transmits apoptotic Ca2+ signals into mitochondria . J. Biol. Chem. . 280 . 49 . 40892–900 . 2006 . 16192275 . 10.1074/jbc.M506623200 . free .
• Bohl J, Brimer N, Lyons C, Vande Pol SB . The stardust family protein MPP7 forms a tripartite complex with LIN7 and DLG1 that regulates the stability and localization of DLG1 to cell junctions . J. Biol. Chem. . 282 . 13 . 9392–400 . 2007 . 17237226 . 10.1074/jbc.M610002200 . free .
• Onda T, Uzawa K, Nakashima D, Saito K, Iwadate Y, Seki N, Shibahara T, Tanzawa H . Lin-7C/VELI3/MALS-3: an essential component in metastasis of human squamous cell carcinoma . Cancer Res. . 67 . 20 . 9643–8 . 2007 . 17942893 . 10.1158/0008-5472.CAN-07-1911 . 10130/633 . free .

Notes and References

1. Jo K, Derin R, Li M, Bredt DS . Characterization of MALS/Velis-1, -2, and -3: a family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex . J Neurosci . 19 . 11 . 4189–99 . Jun 1999 . 10341223 . 6782594. 10.1523/JNEUROSCI.19-11-04189.1999. free .
2. Web site: Entrez Gene: LIN7C lin-7 homolog C (C. elegans).
3. Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA . A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels . J. Biol. Chem. . 279 . 18 . 19051–63 . Apr 2004 . 14960569 . 10.1074/jbc.M400284200 . free .
4. Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA . Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins . J. Biol. Chem. . 279 . 21 . 22331–46 . May 2004 . 15024025 . 10.1074/jbc.M400285200 . free .