LIN7A explained

Lin-7 homolog A is a protein that in humans is encoded by the LIN7A gene.^{[1] [2] [3]}

Interactions

LIN7A has been shown to interact with:

• CASK,^[4]
• DLG1, and
• KCNJ12.^{[5] [6]}

Further reading

• Rousset R, Fabre S, Desbois C, Bantignies F, Jalinot P . The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins . Oncogene . 16 . 5 . 643–54 . 1998 . 9482110 . 10.1038/sj.onc.1201567 . free .
• Butz S, Okamoto M, Südhof TC . A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain . Cell . 94 . 6 . 773–82 . 1998 . 9753324 . 10.1016/S0092-8674(00)81736-5 . 12465062 . free .
• Borg JP, Straight SW, Kaech SM, de Taddéo-Borg M, Kroon DE, Karnak D, Turner RS, Kim SK, Margolis B . Identification of an evolutionarily conserved heterotrimeric protein complex involved in protein targeting . J. Biol. Chem. . 273 . 48 . 31633–6 . 1998 . 9822620 . 10.1074/jbc.273.48.31633 . free .
• Borg JP, Lõpez-Figueroa MO, de Taddèo-Borg M, Kroon DE, Turner RS, Watson SJ, Margolis B . Molecular analysis of the X11-mLin-2/CASK complex in brain . J. Neurosci. . 19 . 4 . 1307–16 . 1999 . 9952408 . 10.1523/JNEUROSCI.19-04-01307.1999. 6786035 . free .
• Perego C, Vanoni C, Villa A, Longhi R, Kaech SM, Fröhli E, Hajnal A, Kim SK, Pietrini G . PDZ-mediated interactions retain the epithelial GABA transporter on the basolateral surface of polarized epithelial cells . EMBO J. . 18 . 9 . 2384–93 . 1999 . 10228153 . 1171321 . 10.1093/emboj/18.9.2384 .
• Kamberov E, Makarova O, Roh M, Liu A, Karnak D, Straight S, Margolis B . Molecular cloning and characterization of Pals, proteins associated with mLin-7 . J. Biol. Chem. . 275 . 15 . 11425–31 . 2000 . 10753959 . 10.1074/jbc.275.15.11425 . free .
• Tseng TC, Marfatia SM, Bryant PJ, Pack S, Zhuang Z, O'Brien JE, Lin L, Hanada T, Chishti AH . VAM-1: a new member of the MAGUK family binds to human Veli-1 through a conserved domain . Biochim. Biophys. Acta . 1518 . 3 . 249–59 . 2001 . 11311936 . 10.1016/s0167-4781(01)00191-9 .
• Harris BZ, Venkatasubrahmanyam S, Lim WA . Coordinated folding and association of the LIN-2, -7 (L27) domain. An obligate heterodimerization involved in assembly of signaling and cell polarity complexes . J. Biol. Chem. . 277 . 38 . 34902–8 . 2002 . 12110687 . 10.1074/jbc.M205856200 . free .
• Hori K, Konno D, Maruoka H, Sobue K . MALS is a binding partner of IRSp53 at cell-cell contacts . FEBS Lett. . 554 . 1–2 . 30–4 . 2003 . 14596909 . 10.1016/S0014-5793(03)01074-3 . 30329043 . free .
• Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA . A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels . J. Biol. Chem. . 279 . 18 . 19051–63 . 2004 . 14960569 . 10.1074/jbc.M400284200 . free .
• Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA . Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins . J. Biol. Chem. . 279 . 21 . 22331–46 . 2004 . 15024025 . 10.1074/jbc.M400285200 . free .
• Olsen O, Wade JB, Morin N, Bredt DS, Welling PA . Differential localization of mammalian Lin-7 (MALS/Veli) PDZ proteins in the kidney . Am. J. Physiol. Renal Physiol. . 288 . 2 . F345–52 . 2005 . 15494546 . 10.1152/ajprenal.00235.2004 . 36221552 .
• Dode L, Andersen JP, Raeymaekers L, Missiaen L, Vilsen B, Wuytack F . Functional comparison between secretory pathway Ca2+/Mn2+-ATPase (SPCA) 1 and sarcoplasmic reticulum Ca2+-ATPase (SERCA) 1 isoforms by steady-state and transient kinetic analyses . J. Biol. Chem. . 280 . 47 . 39124–34 . 2006 . 16192278 . 10.1074/jbc.M506181200 . free .

Notes and References

1. Jo K, Derin R, Li M, Bredt DS . Characterization of MALS/Velis-1, -2, and -3: a family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex . J Neurosci . 19 . 11 . 4189–99 . Jun 1999 . 10341223 . 6782594. 10.1523/JNEUROSCI.19-11-04189.1999. free .
2. Bohl J, Brimer N, Lyons C, Vande Pol SB . The stardust family protein MPP7 forms a tripartite complex with LIN7 and DLG1 that regulates the stability and localization of DLG1 to cell junctions . J Biol Chem . 282 . 13 . 9392–400 . Mar 2007 . 17237226 . 10.1074/jbc.M610002200 . free .
3. Web site: Entrez Gene: LIN7A lin-7 homolog A (C. elegans).
4. Borg JP, Straight SW, Kaech SM, de Taddéo-Borg M, Kroon DE, Karnak D, Turner RS, Kim SK, Margolis B . Identification of an evolutionarily conserved heterotrimeric protein complex involved in protein targeting . J. Biol. Chem. . 273 . 48 . 31633–6 . Nov 1998 . 9822620 . 10.1074/jbc.273.48.31633. free .
5. Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA . A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels . J. Biol. Chem. . 279 . 18 . 19051–63 . Apr 2004 . 14960569 . 10.1074/jbc.M400284200 . free .
6. Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA . Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins . J. Biol. Chem. . 279 . 21 . 22331–46 . May 2004 . 15024025 . 10.1074/jbc.M400285200 . free .