KCNJ12 explained

ATP-sensitive inward rectifier potassium channel 12 is a lipid-gated ion channel that in humans is encoded by the KCNJ12 gene.^{[1] [2] [3] [4] [5]}

Function

This gene encodes an inwardly rectifying K⁺ channel that may be blocked by divalent cations. This protein is thought to be one of multiple inwardly rectifying channels that contribute to the cardiac inward rectifier current (IK1). The gene is located within the Smith–Magenis syndrome region on chromosome 17.^[5]

Interactions

KCNJ12 has been shown to interact with:

• APBA1,
• CASK,
• DLG1,^[6]
• DLG2,
• DLG3,
• DLG4,
  • LIN7A LIN7B, and
• LIN7C.^{[7] [8]}

See also

• Inward-rectifier potassium channel

References

Further reading

• Namba N, Inagaki N, Gonoi T, Seino Y, Seino S . Kir2.2v: a possible negative regulator of the inwardly rectifying K+ channel Kir2.2 . FEBS Letters . 386 . 2–3 . 211–4 . May 1996 . 8647284 . 10.1016/0014-5793(96)00445-0 . 44673403 . free . 1996FEBSL.386..211N .
• Hugnot JP, Pedeutour F, Le Calvez C, Grosgeorge J, Passage E, Fontes M, Lazdunski M . The human inward rectifying K+ channel Kir 2.2 (KCNJ12) gene: gene structure, assignment to chromosome 17p11.1, and identification of a simple tandem repeat polymorphism . Genomics . 39 . 1 . 113–6 . Jan 1997 . 9027495 . 10.1006/geno.1996.4450 .
• Gallagher PG, Forget BG . An alternate promoter directs expression of a truncated, muscle-specific isoform of the human ankyrin 1 gene . The Journal of Biological Chemistry . 273 . 3 . 1339–48 . Jan 1998 . 9430667 . 10.1074/jbc.273.3.1339 . free .
• Namba N, Mori R, Tanaka H, Kondo I, Narahara K, Seino Y . The inwardly rectifying potassium channel subunit Kir2.2v (KCNJN1) maps to 17p11.2→p11.1 . Cytogenetics and Cell Genetics . 79 . 1–2 . 85–7 . 1998 . 9533018 . 10.1159/000134688 .
• Leonoudakis D, Mailliard W, Wingerd K, Clegg D, Vandenberg C . Inward rectifier potassium channel Kir2.2 is associated with synapse-associated protein SAP97 . Journal of Cell Science . 114 . Pt 5 . 987–98 . Mar 2001 . 10.1242/jcs.114.5.987 . 11181181 . free .
• Preisig-Müller R, Schlichthörl G, Goerge T, Heinen S, Brüggemann A, Rajan S, Derst C, Veh RW, Daut J . Heteromerization of Kir2.x potassium channels contributes to the phenotype of Andersen's syndrome . Proceedings of the National Academy of Sciences of the United States of America . 99 . 11 . 7774–9 . May 2002 . 12032359 . 124349 . 10.1073/pnas.102609499 . 2002PNAS...99.7774P . free .
• Chen L, Kawano T, Bajic S, Kaziro Y, Itoh H, Art JJ, Nakajima Y, Nakajima S . A glutamate residue at the C terminus regulates activity of inward rectifier K+ channels: implication for Andersen's syndrome . Proceedings of the National Academy of Sciences of the United States of America . 99 . 12 . 8430–5 . Jun 2002 . 12034888 . 123084 . 10.1073/pnas.122682899 . 2002PNAS...99.8430C . free .
• Karkanis T, Li S, Pickering JG, Sims SM . Plasticity of KIR channels in human smooth muscle cells from internal thoracic artery . American Journal of Physiology. Heart and Circulatory Physiology . 284 . 6 . H2325–34 . Jun 2003 . 12598232 . 10.1152/ajpheart.00559.2002 .
• Stonehouse AH, Grubb BD, Pringle JH, Norman RI, Stanfield PR, Brammar WJ . Nuclear immunostaining in rat neuronal cells using two anti-Kir2.2 ion channel polyclonal antibodies . Journal of Molecular Neuroscience . 20 . 2 . 189–94 . Apr 2003 . 12794312 . 10.1385/JMN:20:2:189 . 34958415 .
• Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA . A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels . The Journal of Biological Chemistry . 279 . 18 . 19051–63 . Apr 2004 . 14960569 . 10.1074/jbc.M400284200 . free .
• Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA . Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins . The Journal of Biological Chemistry . 279 . 21 . 22331–46 . May 2004 . 15024025 . 10.1074/jbc.M400285200 . free .
• Fang Y, Schram G, Romanenko VG, Shi C, Conti L, Vandenberg CA, Davies PF, Nattel S, Levitan I . Functional expression of Kir2.x in human aortic endothelial cells: the dominant role of Kir2.2 . American Journal of Physiology. Cell Physiology . 289 . 5 . C1134–44 . Nov 2005 . 15958527 . 10.1152/ajpcell.00077.2005 . 11840480 .
• Kiesecker C, Zitron E, Scherer D, Lueck S, Bloehs R, Scholz EP, Pirot M, Kathöfer S, Thomas D, Kreye VA, Kiehn J, Borst MM, Katus HA, Schoels W, Karle CA . Regulation of cardiac inwardly rectifying potassium current IK1 and Kir2.x channels by endothelin-1 . Journal of Molecular Medicine . 84 . 1 . 46–56 . Jan 2006 . 16258766 . 10.1007/s00109-005-0707-8 . 2081384 .

Notes and References

1. Hansen . SB . Lipid agonism: The PIP2 paradigm of ligand-gated ion channels. . Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids . May 2015 . 1851 . 5 . 620–8 . 10.1016/j.bbalip.2015.01.011 . 25633344. 4540326 .
2. Wible BA, De Biasi M, Majumder K, Taglialatela M, Brown AM . Cloning and functional expression of an inwardly rectifying K+ channel from human atrium . Circulation Research . 76 . 3 . 343–50 . Mar 1995 . 7859381 . 10.1161/01.res.76.3.343 .
3. Kaibara M, Ishihara K, Doi Y, Hayashi H, Ehara T, Taniyama K . Identification of human Kir2.2 (KCNJ12) gene encoding functional inward rectifier potassium channel in both mammalian cells and Xenopus oocytes . FEBS Letters . 531 . 2 . 250–4 . Nov 2002 . 12417321 . 10.1016/S0014-5793(02)03512-3 . 46515689 . free . 2002FEBSL.531..250K .
4. Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y, Lazdunski M, Nichols CG, Seino S, Vandenberg CA . International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels . Pharmacological Reviews . 57 . 4 . 509–26 . Dec 2005 . 16382105 . 10.1124/pr.57.4.11 . 11588492 .
5. Web site: Entrez Gene: KCNJ12 potassium inwardly-rectifying channel, subfamily J, member 12.
6. Leonoudakis D, Mailliard W, Wingerd K, Clegg D, Vandenberg C . Inward rectifier potassium channel Kir2.2 is associated with synapse-associated protein SAP97 . Journal of Cell Science . 114 . Pt 5 . 987–98 . Mar 2001 . 10.1242/jcs.114.5.987 . 11181181 . free .
7. Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA . Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins . The Journal of Biological Chemistry . 279 . 21 . 22331–46 . May 2004 . 15024025 . 10.1074/jbc.M400285200 . free .
8. Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA . A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels . The Journal of Biological Chemistry . 279 . 18 . 19051–63 . Apr 2004 . 14960569 . 10.1074/jbc.M400284200 . free .