| State: | KY |
| Type: | KY |
| Route: | 680 |
| Length Mi: | 18.728 |
| Length Ref: | [1] |
| Direction A: | West |
| Terminus A: | south-southeast of Eastern |
| Junction: | in Minnie and McDowell |
| Direction B: | East |
| Terminus B: | in Harold |
| Counties: | Floyd |
| Previous Type: | KY |
| Previous Route: | 679 |
| Next Type: | KY |
| Next Route: | 681 |
Kentucky Route 680 (KY 680) is an 18.728adj=midNaNadj=mid state highway in Kentucky. KY 680's western terminus is at KY 80 south-southeast of Eastern, and the eastern terminus is at U.S. Route 23 (US 23), US 460 and KY 80 in Harold