| State: | KY |
| Type: | KY |
| Route: | 388 |
| Map Custom: | yes |
| Length Mi: | 12.937 |
| Length Round: | 3 |
| Length Ref: | [1] |
| Direction A: | South |
| Terminus A: | in Richmond |
| Direction B: | North |
| Terminus B: | at Boonesborough |
| Counties: | Madison |
| Previous Type: | KY |
| Previous Route: | 387 |
| Next Type: | KY |
| Next Route: | 389 |
Kentucky Route 388 (KY 388) is a 12.937miles state highway in Madison County, Kentucky, that runs from U.S. Route 25 Business, Kentucky Route 52, and South Second Street in downtown Richmond to Kentucky Route 627 just to the west of Boonesborough. The route passes through Fort Boonesborough State Park, and also comes within 0.5miles of Clark County.