| State: | KY |
| Type: | KY |
| Route: | 354 |
| Map Custom: | yes |
| Map Notes: | KY 354 highlighted in red |
| Alternate Name: | Tobacco Road |
| Length Mi: | 1.106 |
| Length Round: | 3 |
| Direction A: | South |
| Terminus A: | in London |
| Direction B: | North |
| Terminus B: | in London |
| Counties: | Laurel |
| Previous Type: | KY |
| Previous Route: | 353 |
| Next Type: | KY |
| Next Route: | 355 |
Kentucky Route 354 (KY 354) is a 1.106adj=midNaNadj=mid state highway in the U.S. state of Kentucky. The highway travels through portions of London, in Laurel County.
KY 354 begins at an intersection with KY 80 (East 4th Street) in the northeastern part of London, within Laurel County. It travels to the north-northwest, paralleling railroad tracks of CSX. It curves to the north-northeast, leaving the railroad tracks. It curves to the northwest and the north-northwest and meets its northern terminus, an intersection with the Hal Rogers Parkway. Here, the roadway continues as KY 30.