| Karel De Smet | |
| Birth Date: | 21 August 1980 |
| Birth Place: | Ghent, Belgium |
| Currentclub: | KFC Merelbeke |
| Position: | Centre back |
| Youthclubs1: | KFC Eendracht Moortsele |
| Years1: | 1999–2000 |
| Caps1: | 10 |
| Goals1: | 0 |
| Years2: | 2001 |
| Caps2: | 12 |
| Goals2: | 1 |
| Years3: | 2001–2002 |
| Caps3: | 30 |
| Goals3: | 4 |
| Years4: | 2002–2009 |
| Caps4: | 210 |
| Goals4: | 21 |
| Years5: | 2009–2011 |
| Caps5: | 60 |
| Goals5: | 2 |
| Years6: | 2011–2012 |
| Caps6: | 42 |
| Goals6: | 0 |
| Years7: | 2013 |
| Clubs7: | Daejeon Citizen[1] |
| Caps7: | 0 |
| Goals7: | 0 |
| Years8: | 2014– |
| Clubs8: | KFC Merelbeke |
| Pcupdate: | 1 November 2015 |
Karel De Smet (born 21 August 1980) is a Belgian footballer who plays as centre back for KFC Merelbeke.