The Karate competition at the 2005 Mediterranean Games was held in the Rafael Florido Sports Hall in Almería, Spain.
| 60 kg |  Montassar Tabben |  Davíd Luque |  Şevket Baştürk Davy Dona | |
| 65 kg |  Ciro Massa | Antonio Sánchez | Mehdi Alloune Hassib Kanoun | |
| 70 kg |  Mohamed El Shemy | Óscar Vázquez | Giuseppe Di Domenico Koceila Hamadini | |
| 75 kg | Olivier Beaudry |  Adnan Hadžić | Konstantinos Papadopoulos Yacine Gouri | |
| 80 kg | Iván Leal | Miloš Živković | Mohamed Hammouda Zeynel Çelik | |
| +80 kg | Stefano Maniscalco | Almir Cecunjanin | Francisco Martínez Spyridon Margaritopoulos | |
| Open | Stefano Maniscalco | Yann Baillon | Mohamed El Hamid Yusuf Başer |
| 50 kg | Heba Aly | Natalia García | Vildan Doğan Vanessa Ruiz | |
| 55 kg | Selene Guglielmi | Ilhem Eldjon | Estefania García Teja Šavor | |
| 60 kg | Snežana Pantić | Petra Narandja | Noelia Fernández Rafika Dakhlaoui | |
| 65 kg | Arnela Odžaković | Gloria Rodríguez | Alexia Karypidou Gülcihan Ustaoğlu | |
| +65 kg | Cristina Feo | Yıldız Aras | Emmeline Mottet Greta Vitelli | |
| Open | Yıldız Aras | Gloria Rodríguez | Rafika Dakhlaoui Merima Softić |