KRT86 explained
The KRT86 gene encodes for keratin, type II cuticular Hb6 protein in humans.[1] [2] [3]
The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRT81, KRT83, and KRT86, is highly related. The other, less-related subfamily includes KRT82, KRT84, and KRT85. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRT81 and KRT83, is found primarily in the hair cortex. Mutations in this gene and KRT81 have been observed in patients with a rare dominant hair disease, monilethrix.
Further reading
- Langbein L, Schweizer J . Keratins of the human hair follicle . Int. Rev. Cytol. . International Review of Cytology . 243 . 1–78 . 2005 . 15797458 . 10.1016/S0074-7696(05)43001-6 . 9780123646477 .
- Rogers MA, Nischt R, Korge B, etal . Sequence data and chromosomal localization of human type I and type II hair keratin genes . Exp. Cell Res. . 220 . 2 . 357–62 . 1995 . 7556444 . 10.1006/excr.1995.1326 .
- Rogers MA, Langbein L, Praetzel S, etal . Sequences and differential expression of three novel human type-II hair keratins . Differentiation . 61 . 3 . 187–94 . 1997 . 9084137 . 10.1046/j.1432-0436.1997.6130187.x .
- Winter H, Rogers MA, Gebhardt M, etal . A new mutation in the type II hair cortex keratin hHb1 involved in the inherited hair disorder monilethrix . Hum. Genet. . 101 . 2 . 165–9 . 1998 . 9402962 . 10.1007/s004390050607 . 20555394 .
- Bowden PE, Hainey SD, Parker G, etal . Characterization and chromosomal localization of human hair-specific keratin genes and comparative expression during the hair growth cycle . J. Invest. Dermatol. . 110 . 2 . 158–64 . 1998 . 9457912 . 10.1046/j.1523-1747.1998.00097.x . free .
- Winter H, Clark RD, Tarras-Wahlberg C, etal . Monilethrix: a novel mutation (Glu402Lys) in the helix termination motif and the first causative mutation (Asn114Asp) in the helix initiation motif of the type II hair keratin hHb6 . J. Invest. Dermatol. . 113 . 2 . 263–6 . 1999 . 10469314 . 10.1046/j.1523-1747.1999.00685.x . free .
- Korge BP, Hamm H, Jury CS, etal . Identification of novel mutations in basic hair keratins hHb1 and hHb6 in monilethrix: implications for protein structure and clinical phenotype . J. Invest. Dermatol. . 113 . 4 . 607–12 . 1999 . 10504448 . 10.1046/j.1523-1747.1999.00722.x . free .
- Pearce EG, Smith SK, Lanigan SW, Bowden PE . Two different mutations in the same codon of a type II hair keratin (hHb6) in patients with monilethrix . J. Invest. Dermatol. . 113 . 6 . 1123–7 . 2000 . 10594761 . 10.1046/j.1523-1747.1999.00777.x . free .
- Rogers MA, Winter H, Langbein L, etal . Characterization of a 300 kbp region of human DNA containing the type II hair keratin gene domain . J. Invest. Dermatol. . 114 . 3 . 464–72 . 2000 . 10692104 . 10.1046/j.1523-1747.2000.00910.x . free .
- Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
- Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
Notes and References
- Winter H, Rogers MA, Langbein L, Stevens HP, Leigh IM, Labreze C, Roul S, Taieb A, Krieg T, Schweizer J . . Nat Genet . 16 . 4 . 372–4 . Aug 1997 . 9241275 . 10.1038/ng0897-372 . 25352502 .
- Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW . New consensus nomenclature for mammalian keratins . J Cell Biol . 174 . 2 . 169–74 . Jul 2006 . 16831889 . 2064177 . 10.1083/jcb.200603161 .
- Web site: Entrez Gene: KRT86 keratin 86.