KRT32 explained
Keratin, type I cuticular Ha2 is a protein that in humans is encoded by the KRT32 gene.[1] [2] [3] [4]
The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II hair keratin to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q21.2 and have the same direction of transcription.[4]
Further reading
- Yu J, Yu DW, Checkla DM, etal . Human hair keratins . J. Invest. Dermatol. . 101 . 1 Suppl . 56S–59S . 1993 . 7686952 . 10.1111/1523-1747.ep12362635 .
- Ewing RM, Chu P, Elisma F, etal . Large-scale mapping of human protein–protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 .
- Adkins JN, Varnum SM, Auberry KJ, etal . Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry . Mol. Cell. Proteomics . 1 . 12 . 947–55 . 2003 . 12543931 . 10.1074/mcp.M200066-MCP200. free .
- Langbein L, Rogers MA, Winter H, etal . The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle . J. Biol. Chem. . 274 . 28 . 19874–84 . 1999 . 10391933 . 10.1074/jbc.274.28.19874 . free .
- Heid HW, Moll I, Franke WW . Patterns of expression of trichocytic and epithelial cytokeratins in mammalian tissues. I. Human and bovine hair follicles . Differentiation . 37 . 2 . 137–57 . 1988 . 2456239 . 10.1111/j.1432-0436.1988.tb00805.x .
Notes and References
- Rogers MA, Nischt R, Korge B, Krieg T, Fink TM, Lichter P, Winter H, Schweizer J . Sequence data and chromosomal localization of human type I and type II hair keratin genes . Exp Cell Res . 220 . 2 . 357–62 . Nov 1995 . 7556444 . 10.1006/excr.1995.1326 .
- Rogers MA, Winter H, Langbein L, Krieg T, Schweizer J . Genomic characterization of the human type I cuticular hair keratin hHa2 and identification of an adjacent novel type I hair keratin gene hHa5 . J Invest Dermatol . 107 . 4 . 633–8 . Dec 1996 . 8823373 . 10.1111/1523-1747.ep12584243 . free .
- Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW . New consensus nomenclature for mammalian keratins . J Cell Biol . 174 . 2 . 169–74 . Jul 2006 . 16831889 . 2064177 . 10.1083/jcb.200603161 .
- Web site: Entrez Gene: KRT32 keratin 32.