KCNJ9 explained

G protein-activated inward rectifier potassium channel 3 is a protein that in humans is encoded by the KCNJ9 gene.^{[1] [2] [3]}

Function

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. It associates with another G-protein-activated potassium channel to form a heteromultimeric pore-forming complex.

Interactions

KCNJ9 has been shown to interact with KCNJ6.^{[4] [5]}

See also

• G protein-coupled inwardly-rectifying potassium channel
• Inward-rectifier potassium ion channel

Further reading

• Jelacic TM, Sims SM, Clapham DE . Functional expression and characterization of G-protein-gated inwardly rectifying K+ channels containing GIRK3 . The Journal of Membrane Biology . 169 . 2 . 123–9 . May 1999 . 10341034 . 10.1007/s002329900524 . 13538678 .
• Schoots O, Wilson JM, Ethier N, Bigras E, Hebert TE, Van Tol HH . Co-expression of human Kir3 subunits can yield channels with different functional properties . Cellular Signalling . 11 . 12 . 871–83 . Dec 1999 . 10659995 . 10.1016/S0898-6568(99)00059-5 .
• Vaughn J, Wolford JK, Prochazka M, Permana PA . Genomic structure and expression of human KCNJ9 (Kir3.3/GIRK3) . Biochemical and Biophysical Research Communications . 274 . 2 . 302–9 . Aug 2000 . 10913335 . 10.1006/bbrc.2000.3136 .
• Jelacic TM, Kennedy ME, Wickman K, Clapham DE . Functional and biochemical evidence for G-protein-gated inwardly rectifying K+ (GIRK) channels composed of GIRK2 and GIRK3 . The Journal of Biological Chemistry . 275 . 46 . 36211–6 . Nov 2000 . 10956667 . 10.1074/jbc.M007087200 . free .
• Lavine N, Ethier N, Oak JN, Pei L, Liu F, Trieu P, Rebois RV, Bouvier M, Hebert TE, Van Tol HH . G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase . The Journal of Biological Chemistry . 277 . 48 . 46010–9 . Nov 2002 . 12297500 . 10.1074/jbc.M205035200 . free .
• Plummer HK, Dhar MS, Cekanova M, Schuller HM . Expression of G-protein inwardly rectifying potassium channels (GIRKs) in lung cancer cell lines . BMC Cancer . 5 . 104 . 2006 . 16109170 . 1208863 . 10.1186/1471-2407-5-104 . free .

Notes and References

1. Lesage F, Fink M, Barhanin J, Lazdunski M, Mattéi MG . Assignment of human G-protein-coupled inward rectifier K+ channel homolog GIRK3 gene to chromosome 1q21-q23 . Genomics . 29 . 3 . 808–9 . Oct 1995 . 8575783 . 10.1006/geno.1995.9928 .
2. Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y, Lazdunski M, Nichols CG, Seino S, Vandenberg CA . International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels . Pharmacological Reviews . 57 . 4 . 509–26 . Dec 2005 . 16382105 . 10.1124/pr.57.4.11 . 11588492 .
3. Web site: Entrez Gene: KCNJ9 potassium inwardly-rectifying channel, subfamily J, member 9.
4. Jelacic TM, Kennedy ME, Wickman K, Clapham DE . Functional and biochemical evidence for G-protein-gated inwardly rectifying K+ (GIRK) channels composed of GIRK2 and GIRK3 . The Journal of Biological Chemistry . 275 . 46 . 36211–6 . Nov 2000 . 10956667 . 10.1074/jbc.M007087200 . free .
5. Lavine N, Ethier N, Oak JN, Pei L, Liu F, Trieu P, Rebois RV, Bouvier M, Hebert TE, Van Tol HH . G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase . The Journal of Biological Chemistry . 277 . 48 . 46010–9 . Nov 2002 . 12297500 . 10.1074/jbc.M205035200 . free .