| Country: | JPN |
| Type: | National |
| Route: | 161 |
| Map Custom: | yes |
| Length Km: | 86.4 |
| Length Ref: | [1] |
| Established: | 18 May 1953 |
| Direction A: | North |
| Terminus A: | in Tsuruga, Fukui |
| Direction B: | South |
| Terminus B: | in Ōtsu |
| Previous Type: | Route |
| Previous Route: | 160 |
| Next Type: | Route |
| Next Route: | 162 |
National Route 161 is a national highway of Japan connecting Tsuruga, Fukui and Ōtsu, Shiga in Japan, with a total length of 86.4km (53.7miles)