| Honorific-Prefix: | Ḥakham |
| Jacob Manasseh | |
| Death Place: | Salonica, Ottoman Empire |
| Yahrtzeit: | 21 Nissan 5592 |
Raphael Jacob Manasseh (; 1762 – 21 April 1832) was an Ottoman rabbinical writer and chief rabbi of Salonica. Among his works are Ohel Ya'aḳob (Salonica, 1832), an alphabetical collection of the laws of religion; Be'er ha-Mayim (Salonica, 1836), responsa; and En ha-Mayim (printed in 1858), a commentary on the Shulchan Aruch and Yoreh De'ah.