Integrin alpha-1 explained

Integrin alpha-1 also CD49a is an integrin alpha subunit encoded in humans by the gene ITGA1. It makes up half of the α1β1 integrin duplex. Though CD49a can bind a number of ligands including collagen IV, collagen I, and others.^[1]

CD49a has been implicated as a marker of tissue resident memory T cells, where it may be coexpressed with other markers CD103 and CD69.^[2] It has been shown to affect the motility of T cells.^[3]

Further reading

• Virtanen I, Korhonen M, Kariniemi AL, Gould VE, Laitinen L, Ylänne J . Integrins in human cells and tumors . Cell Differentiation and Development . 32 . 3 . 215–227 . December 1990 . 2099238 . 10.1016/0922-3371(90)90034-T .
• Plenz GA, Deng MC, Robenek H, Völker W . Vascular collagens: spotlight on the role of type VIII collagen in atherogenesis . Atherosclerosis . 166 . 1 . 1–11 . January 2003 . 12482545 . 10.1016/S0021-9150(01)00766-3 .
• Clover J, Dodds RA, Gowen M . Integrin subunit expression by human osteoblasts and osteoclasts in situ and in culture . Journal of Cell Science . 103 (Pt 1) . 1 . 267–271 . September 1992 . 1429908 . 10.1242/jcs.103.1.267 .
• Bodary SC, McLean JW . The integrin beta 1 subunit associates with the vitronectin receptor alpha v subunit to form a novel vitronectin receptor in a human embryonic kidney cell line . The Journal of Biological Chemistry . 265 . 11 . 5938–5941 . April 1990 . 1690718 . 10.1016/S0021-9258(19)39269-5 . free .
• Sonnenberg A, Linders CJ, Modderman PW, Damsky CH, Aumailley M, Timpl R . Integrin recognition of different cell-binding fragments of laminin (P1, E3, E8) and evidence that alpha 6 beta 1 but not alpha 6 beta 4 functions as a major receptor for fragment E8 . The Journal of Cell Biology . 110 . 6 . 2145–2155 . June 1990 . 1693624 . 2116116 . 10.1083/jcb.110.6.2145 .
• Belkin VM, Belkin AM, Dol'nikova AE, Tarasova EA, Kotelianskiĭ VE . [Isolation and characteristics of ligand specificity of VLA-1 integrin from human smooth muscles] . Biokhimiia . 56 . 12 . 2198–2206 . December 1991 . 1807406 .
• Bank I, Roth D, Book M, Guterman A, Shnirrer I, Block R, Ehrenfeld M, Langevitz P, Brenner H, Pras M . Expression and functions of very late antigen 1 in inflammatory joint diseases . Journal of Clinical Immunology . 11 . 1 . 29–38 . January 1991 . 1827128 . 10.1007/BF00918792 . 6198792 .
• Tabibzadeh S . Evidence of T-cell activation and potential cytokine action in human endometrium . The Journal of Clinical Endocrinology and Metabolism . 71 . 3 . 645–649 . September 1990 . 2144294 . 10.1210/jcem-71-3-645 .
• Tawil NJ, Houde M, Blacher R, Esch F, Reichardt LF, Turner DC, Carbonetto S . Alpha 1 beta 1 integrin heterodimer functions as a dual laminin/collagen receptor in neural cells . Biochemistry . 29 . 27 . 6540–6544 . July 1990 . 2169872 . 2710132 . 10.1021/bi00479a028 .
• Belkin VM, Belkin AM, Koteliansky VE . Human smooth muscle VLA-1 integrin: purification, substrate specificity, localization in aorta, and expression during development . The Journal of Cell Biology . 111 . 5 Pt 1 . 2159–2170 . November 1990 . 2229189 . 2116325 . 10.1083/jcb.111.5.2159 .
• MacDonald TT, Horton MA, Choy MY, Richman PI . Increased expression of laminin/collagen receptor (VLA-1) on epithelium of inflamed human intestine . Journal of Clinical Pathology . 43 . 4 . 313–315 . April 1990 . 2341567 . 502365 . 10.1136/jcp.43.4.313 .
• Takada Y, Strominger JL, Hemler ME . The very late antigen family of heterodimers is part of a superfamily of molecules involved in adhesion and embryogenesis . Proceedings of the National Academy of Sciences of the United States of America . 84 . 10 . 3239–3243 . May 1987 . 3033641 . 304844 . 10.1073/pnas.84.10.3239 . free . 1987PNAS...84.3239T .
• Hemler ME, Huang C, Schwarz L . The VLA protein family. Characterization of five distinct cell surface heterodimers each with a common 130,000 molecular weight beta subunit . The Journal of Biological Chemistry . 262 . 7 . 3300–3309 . March 1987 . 3546305 . 10.1016/S0021-9258(18)61504-2 . free .
• Kono Y, Yang S, Letarte M, Roberts EA . Establishment of a human hepatocyte line derived from primary culture in a collagen gel sandwich culture system . Experimental Cell Research . 221 . 2 . 478–485 . December 1995 . 7493648 . 10.1006/excr.1995.1399 .
• Eglinton BA, Roberton DM, Cummins AG . Phenotype of T cells, their soluble receptor levels, and cytokine profile of human breast milk . Immunology and Cell Biology . 72 . 4 . 306–313 . August 1994 . 7806264 . 10.1038/icb.1994.46 . 25016970 .
• Salter DM, Godolphin JL, Gourlay MS . Chondrocyte heterogeneity: immunohistologically defined variation of integrin expression at different sites in human fetal knees . The Journal of Histochemistry and Cytochemistry . 43 . 4 . 447–457 . April 1995 . 7897185 . 10.1177/43.4.7897185 . free .
• Pfaff M, Aumailley M, Specks U, Knolle J, Zerwes HG, Timpl R . Integrin and Arg-Gly-Asp dependence of cell adhesion to the native and unfolded triple helix of collagen type VI . Experimental Cell Research . 206 . 1 . 167–176 . May 1993 . 8387021 . 10.1006/excr.1993.1134 .
• Briesewitz R, Epstein MR, Marcantonio EE . Expression of native and truncated forms of the human integrin alpha 1 subunit . The Journal of Biological Chemistry . 268 . 4 . 2989–2996 . February 1993 . 8428973 . 10.1016/S0021-9258(18)53871-0 . free .
• Langholz O, Röckel D, Mauch C, Kozlowska E, Bank I, Krieg T, Eckes B . Collagen and collagenase gene expression in three-dimensional collagen lattices are differentially regulated by alpha 1 beta 1 and alpha 2 beta 1 integrins . The Journal of Cell Biology . 131 . 6 Pt 2 . 1903–1915 . December 1995 . 8557756 . 2120685 . 10.1083/jcb.131.6.1903 .
• Gardner H, Kreidberg J, Koteliansky V, Jaenisch R . Deletion of integrin alpha 1 by homologous recombination permits normal murine development but gives rise to a specific deficit in cell adhesion . Developmental Biology . 175 . 2 . 301–313 . May 1996 . 8626034 . 10.1006/dbio.1996.0116 . free .

External links

• • • ITGA1 Info with links in the Cell Migration Gateway
• PDBe-KB provides an overview of all the structure information available in the PDB for Human Integrin alpha-1

Notes and References

1. Book: Gardner . Humphrey . Integrin α1β1 . I Domain Integrins . Advances in Experimental Medicine and Biology . 2014 . 819 . 21–39 . 10.1007/978-94-017-9153-3_2. 25023165 . 978-94-017-9152-6 .
2. Reilly EC, Sportiello M, Emo KL, Amitrano AM, Jha R, Kumar AB, Laniewski NG, Yang H, Kim M, Topham DJ . CD49a Identifies Polyfunctional Memory CD8 T Cell Subsets that Persist in the Lungs After Influenza Infection . Frontiers in Immunology . 12 . 728669 . 9 September 2021 . 34566986 . 8462271 . 10.3389/fimmu.2021.728669 . free .
3. Reilly EC, Lambert Emo K, Buckley PM, Reilly NS, Smith I, Chaves FA, Yang H, Oakes PW, Topham DJ . T_RM integrins CD103 and CD49a differentially support adherence and motility after resolution of influenza virus infection . Proceedings of the National Academy of Sciences of the United States of America . 117 . 22 . 12306–12314 . June 2020 . 32439709 . 7275699 . 10.1073/pnas.1915681117 . free .