Integrin beta 3 explained

Integrin beta-3 (β3) or CD61 is a protein that in humans is encoded by the ITGB3 gene.^[1] CD61 is a cluster of differentiation found on thrombocytes.^[2]

Structure and function

The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface-mediated signaling.^[3]

Role in endometriosis

Defectively expressed β3 integrin subunit has been correlated with presence of endometriosis, and has been suggested as a putative marker of this condition.^[4]

Interactions

CD61 has been shown to interact with PTK2,^{[5] [6]} ITGB3BP,^{[7] [8]} TLN1^{[9] [10]} and CIB1.^[11]

See also

• Glycoprotein IIb/IIIa

Further reading

• Bray PF . Inherited diseases of platelet glycoproteins: considerations for rapid molecular characterization . Thrombosis and Haemostasis . 72 . 4 . 492–502 . October 1994 . 7878622 .
• Bennett JS . Platelet-fibrinogen interactions . Annals of the New York Academy of Sciences . 936 . 1 . 340–354 . 2001 . 11460491 . 10.1111/j.1749-6632.2001.tb03521.x . 25431334 . 2001NYASA.936..340B .
• Sajid M, Stouffer GA . The role of alpha(v)beta3 integrins in vascular healing . Thrombosis and Haemostasis . 87 . 2 . 187–193 . February 2002 . 11858476 . 10.1055/s-0037-1612971 .
• Quinn MJ, Byzova TV, Qin J, Topol EJ, Plow EF . Integrin alphaIIbbeta3 and its antagonism . Arteriosclerosis, Thrombosis, and Vascular Biology . 23 . 6 . 945–952 . June 2003 . 12637342 . 10.1161/01.ATV.0000066686.46338.F1 . free .
• Charakida M, Tousoulis D, Stefanadis C, Toutouzas P . The impact of platelet glycoprotein IIIa and Ia polymorphisms in cardiovascular thrombotic disease . Italian Heart Journal . 4 . 1 . 17–22 . January 2003 . 12690916 .
• Smith FB, Connor JM, Lee AJ, Cooke A, Lowe GD, Rumley A, Fowkes FG . Relationship of the platelet glycoprotein PlA and fibrinogen T/G+1689 polymorphisms with peripheral arterial disease and ischaemic heart disease . Thrombosis Research . 112 . 4 . 209–216 . 2004 . 14987913 . 10.1016/j.thromres.2003.11.010 .
• Fullard JF . The role of the platelet glycoprotein IIb/IIIa in thrombosis and haemostasis . Current Pharmaceutical Design . 10 . 14 . 1567–1576 . 2004 . 15134555 . 10.2174/1381612043384682 .
• Cacciari B, Spalluto G . Non peptidic alphavbeta3 antagonists: recent developments . Current Medicinal Chemistry . 12 . 1 . 51–70 . 2005 . 15638730 . 10.2174/0929867053363522 .
• Watson SP, Auger JM, McCarty OJ, Pearce AC . GPVI and integrin alphaIIb beta3 signaling in platelets . Journal of Thrombosis and Haemostasis . 3 . 8 . 1752–1762 . August 2005 . 16102042 . 10.1111/j.1538-7836.2005.01429.x . 42666713 .
• Bennett JS . Structure and function of the platelet integrin alphaIIbbeta3 . The Journal of Clinical Investigation . 115 . 12 . 3363–3369 . December 2005 . 16322781 . 1297263 . 10.1172/JCI26989 .

External links

• • ITGB3 Info with links in the Cell Migration Gateway

Notes and References

1. Sosnoski DM, Emanuel BS, Hawkins AL, van Tuinen P, Ledbetter DH, Nussbaum RL, Kaos FT, Schwartz E, Phillips D, Bennett JS . Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and IIIa . The Journal of Clinical Investigation . 81 . 6 . 1993–1998 . June 1988 . 2454952 . 442653 . 10.1172/JCI113548 .
2. Heemskerk JW, Mattheij NJ, Cosemans JM . Platelet-based coagulation: different populations, different functions . Journal of Thrombosis and Haemostasis . 11 . 1 . 2–16 . January 2013 . 23106920 . 10.1111/jth.12045 . 206157070 . free .
3. Web site: Entrez Gene: ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61).
4. May KE, Villar J, Kirtley S, Kennedy SH, Becker CM . Endometrial alterations in endometriosis: a systematic review of putative biomarkers . Human Reproduction Update . 17 . 5 . 637–653 . 2011 . 21672902 . 10.1093/humupd/dmr013 . free .
5. Eliceiri BP, Puente XS, Hood JD, Stupack DG, Schlaepfer DD, Huang XZ, Sheppard D, Cheresh DA . Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling . The Journal of Cell Biology . 157 . 1 . 149–160 . April 2002 . 11927607 . 2173263 . 10.1083/jcb.200109079 .
6. Chung J, Gao AG, Frazier WA . Thrombspondin acts via integrin-associated protein to activate the platelet integrin alphaIIbbeta3 . The Journal of Biological Chemistry . 272 . 23 . 14740–14746 . June 1997 . 9169439 . 10.1074/jbc.272.23.14740 . free .
7. Fujimoto TT, Katsutani S, Shimomura T, Fujimura K . Novel alternatively spliced form of beta(3)-endonexin . Thrombosis Research . 105 . 1 . 63–70 . January 2002 . 11864709 . 10.1016/S0049-3848(01)00405-4 .
8. Shattil SJ, O'Toole T, Eigenthaler M, Thon V, Williams M, Babior BM, Ginsberg MH . Beta 3-endonexin, a novel polypeptide that interacts specifically with the cytoplasmic tail of the integrin beta 3 subunit . The Journal of Cell Biology . 131 . 3 . 807–816 . November 1995 . 7593198 . 2120613 . 10.1083/jcb.131.3.807 .
9. Patil S, Jedsadayanmata A, Wencel-Drake JD, Wang W, Knezevic I, Lam SC . Identification of a talin-binding site in the integrin beta(3) subunit distinct from the NPLY regulatory motif of post-ligand binding functions. The talin n-terminal head domain interacts with the membrane-proximal region of the beta(3) cytoplasmic tail . The Journal of Biological Chemistry . 274 . 40 . 28575–28583 . October 1999 . 10497223 . 10.1074/jbc.274.40.28575 . free .
10. Calderwood DA, Yan B, de Pereda JM, Alvarez BG, Fujioka Y, Liddington RC, Ginsberg MH . The phosphotyrosine binding-like domain of talin activates integrins . The Journal of Biological Chemistry . 277 . 24 . 21749–21758 . June 2002 . 11932255 . 10.1074/jbc.M111996200 . free .
11. Naik UP, Patel PM, Parise LV . Identification of a novel calcium-binding protein that interacts with the integrin alphaIIb cytoplasmic domain . The Journal of Biological Chemistry . 272 . 8 . 4651–4654 . February 1997 . 9030514 . 10.1074/jbc.272.8.4651 . free .