INSL5 explained

Insulin-like peptide 5 (INSL5) is a protein that in humans is encoded by the INSL5 gene.^{[1] [2]}

Function

The protein encoded by this gene contains a classical signature of the insulin superfamily and is highly similar to relaxin 3 (RLN3/INSL7).

Further reading

• Liu C, Kuei C, Sutton S, Chen J, Bonaventure P, Wu J, Nepomuceno D, Kamme F, Tran DT, Zhu J, Wilkinson T, Bathgate R, Eriste E, Sillard R, Lovenberg TW . INSL5 is a high affinity specific agonist for GPCR142 (GPR100) . The Journal of Biological Chemistry . 280 . 1 . 292–300 . January 2005 . 15525639 . 10.1074/jbc.M409916200 . free .
• Zhang Z, Henzel WJ . Signal peptide prediction based on analysis of experimentally verified cleavage sites . Protein Science . 13 . 10 . 2819–24 . October 2004 . 15340161 . 2286551 . 10.1110/ps.04682504 .
• Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A . The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment . Genome Research . 13 . 10 . 2265–70 . October 2003 . 12975309 . 403697 . 10.1101/gr.1293003 .
• Koman A, Cazaubon S, Couraud PO, Ullrich A, Strosberg AD . Molecular characterization and in vitro biological activity of placentin, a new member of the insulin gene family . The Journal of Biological Chemistry . 271 . 34 . 20238–41 . August 1996 . 8702754 . 10.1074/jbc.271.34.20238 . free .

Notes and References

1. Conklin D, Lofton-Day CE, Haldeman BA, Ching A, Whitmore TE, Lok S, Jaspers S . Identification of INSL5, a new member of the insulin superfamily . Genomics . 60 . 1 . 50–6 . August 1999 . 10458910 . 10.1006/geno.1999.5899 .
2. Web site: Entrez Gene: INSL5 insulin-like 5.