IGF2BP2 explained
Insulin-like growth factor 2 mRNA-binding protein 2 is a protein that in humans is encoded by the IGF2BP2 gene.[1] [2] [3]
This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains four KH domains and two RRM domains. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[4]
See also
Further reading
- Yisraeli JK . VICKZ proteins: a multi-talented family of regulatory RNA-binding proteins. . Biol. Cell . 97 . 1 . 87–96 . 2005 . 15601260 . 10.1042/BC20040151 . 8767105 . free .
- Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
- Moraes KC, Quaresma AJ, Maehnss K, Kobarg J . Identification and characterization of proteins that selectively interact with isoforms of the mRNA binding protein AUF1 (hnRNP D). . Biol. Chem. . 384 . 1 . 25–37 . 2003 . 12674497 . 10.1515/BC.2003.004 . 30993043 .
- Brants JR, Ayoubi TA, Chada K, etal . Differential regulation of the insulin-like growth factor II mRNA-binding protein genes by architectural transcription factor HMGA2. . FEBS Lett. . 569 . 1–3 . 277–83 . 2004 . 15225648 . 10.1016/j.febslet.2004.05.075 . 31167314 . free .
- Ping S, Wang S, Zhang J, Peng X . Effect of all-trans-retinoic acid on mRNA binding protein p62 in human gastric cancer cells . Int. J. Biochem. Cell Biol. . 37 . 3 . 616–27 . 2005 . 15618018 . 10.1016/j.biocel.2004.08.007 .
- Hammer NA, Hansen TO, Byskov AG, etal . Expression of IGF-II mRNA-binding proteins (IMPs) in gonads and testicular cancer . Reproduction . 130 . 2 . 203–12 . 2005 . 16049158 . 10.1530/rep.1.00664 . free .
- Natkunam Y, Vainer G, Chen J, etal . Expression of the RNA-binding protein VICKZ in normal hematopoietic tissues and neoplasms . Haematologica . 92 . 2 . 176–83 . 2007 . 17296566 . 10.3324/haematol.10724 . free .
- Ewing RM, Chu P, Elisma F, etal . Large-scale mapping of human protein-protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 .
- Cleynen I, Brants JR, Peeters K, etal . HMGA2 regulates transcription of the Imp2 gene via an intronic regulatory element in cooperation with nuclear factor-kappaB . Mol. Cancer Res. . 5 . 4 . 363–72 . 2007 . 17426251 . 10.1158/1541-7786.MCR-06-0331 . 21026667 .
Notes and References
- Zhang JY, Chan EK, Peng XX, Tan EM . A novel cytoplasmic protein with RNA-binding motifs is an autoantigen in human hepatocellular carcinoma . J Exp Med . 189 . 7 . 1101–10 . May 1999 . 10190901 . 2193003 . 10.1084/jem.189.7.1101 .
- Nielsen J, Christiansen J, Lykke-Andersen J, Johnsen AH, Wewer UM, Nielsen FC . A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development . Mol Cell Biol . 19 . 2 . 1262–70 . Feb 1999 . 9891060 . 116055 . 10.1128/MCB.19.2.1262.
- Web site: Entrez Gene: IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2.
- Web site: Entrez Gene: IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2.
