IGF2BP1 explained

Insulin-like growth factor 2 mRNA-binding protein 1 is a protein that in humans is encoded by the IGF2BP1 gene.^{[1] [2] [3]}

This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation.^[3]

See also

• IGF2BP2
• IGF2BP3

Further reading

• Perycz M, Urbanska AS, Krawczyk P, Parobczak K, Jaworski J . Zipcode binding protein 1 regulates the development of dendritic arbors in hippocampal neurons . J. Neurosci. . 31 . 14 . 5271–85 . 2011 . 21471362 . 10.1523/JNEUROSCI.2387-10.2011 . 6622686 . free .
• Yisraeli JK . VICKZ proteins: a multi-talented family of regulatory RNA-binding proteins . Biol. Cell . 97 . 1 . 87–96 . 2005 . 15601260 . 10.1042/BC20040151 . 8767105 . free .
• Prokipcak RD, Herrick DJ, Ross J . Purification and properties of a protein that binds to the C-terminal coding region of human c-myc mRNA . J. Biol. Chem. . 269 . 12 . 9261–9 . 1994 . 10.1016/S0021-9258(17)37102-8 . 8132663 . free .
• Doyle GA . The c-myc coding region determinant-binding protein: a member of a family of KH domain RNA-binding proteins . Nucleic Acids Res. . 26 . 22 . 5036–44 . 1999 . 9801297 . 10.1093/nar/26.22.5036 . 147974 . vanc. Betz NA . Leeds PF . 3 . Fleisig . AJ . Prokipcak . RD . Ross . J .
• Runge S . H19 RNA binds four molecules of insulin-like growth factor II mRNA-binding protein . J. Biol. Chem. . 275 . 38 . 29562–9 . 2000 . 10875929 . 10.1074/jbc.M001156200 . vanc. Nielsen FC . Nielsen J . 3 . Lykke-Andersen . J . Wewer . UM . Christiansen . J . free.
• Nielsen FC . Cytoplasmic trafficking of IGF-II mRNA-binding protein by conserved KH domains . J. Cell Sci. . 115 . Pt 10 . 2087–97 . 2003 . 11973350 . vanc. Nielsen J . Kristensen MA . 3 . Koch . G . Christiansen . J . 10.1242/jcs.115.10.2087 .
• Lemm I, Ross J . Regulation of c-myc mRNA Decay by Translational Pausing in a Coding Region Instability Determinant . Mol. Cell. Biol. . 22 . 12 . 3959–69 . 2002 . 12024010 . 10.1128/MCB.22.12.3959-3969.2002 . 133878 .
• Ioannidis P . 8q24 Copy number gains and expression of the c-myc mRNA stabilizing protein CRD-BP in primary breast carcinomas . Int. J. Cancer . 104 . 1 . 54–9 . 2003 . 12532419 . 10.1002/ijc.10794 . vanc. Mahaira L . Papadopoulou A . 3 . Teixeira . Manuel R. . Heim . Sverre . Andersen . Johan A. . Evangelou . Evangelos . Dafni . Urania . Pandis . Nikos . 45119038 . free .
• Nielsen J . Nuclear transit of human zipcode-binding protein IMP1 . Biochem. J. . 376 . Pt 2 . 383–91 . 2003 . 12921532 . 10.1042/BJ20030943 . 1223771 . vanc. Adolph SK . Rajpert-De Meyts E . 3 . Lykke-Andersen . Jens . Koch . Grete . Christiansen . Jan . Nielsen . Finn C. .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Gu L, Shigemasa K, Ohama K . Increased expression of IGF II mRNA-binding protein 1 mRNA is associated with an advanced clinical stage and poor prognosis in patients with ovarian cancer . Int. J. Oncol. . 24 . 3 . 671–8 . 2004 . 14767552 . 10.3892/ijo.24.3.671.
• Hansen TV . Dwarfism and Impaired Gut Development in Insulin-Like Growth Factor II mRNA-Binding Protein 1-Deficient Mice . Mol. Cell. Biol. . 24 . 10 . 4448–64 . 2004 . 15121863 . 10.1128/MCB.24.10.4448-4464.2004 . 400488 . vanc. Hammer NA . Nielsen J . 3 . Madsen . M. . Dalbaeck . C. . Wewer . U. M. . Christiansen . J. . Nielsen . F. C. .
• Ioannidis P . Expression of the RNA-binding protein CRD-BP in brain and non-small cell lung tumors . Cancer Lett. . 209 . 2 . 245–50 . 2004 . 15159028 . 10.1016/j.canlet.2003.12.015 . vanc. Kottaridi C . Dimitriadis E . 3 . Courtis . Nelly . Mahaira . Louiza . Talieri . Maroulio . Giannopoulos . Andreas . Iliadis . Kosmas . Papaioannou . Dimitrios .
• Rackham O, Brown CM . Visualization of RNA–protein interactions in living cells: FMRP and IMP1 interact on mRNAs . EMBO J. . 23 . 16 . 3346–55 . 2005 . 15282548 . 10.1038/sj.emboj.7600341 . 514514 .
• Nielsen J . Sequential dimerization of human zipcode-binding protein IMP1 on RNA: a cooperative mechanism providing RNP stability . Nucleic Acids Res. . 32 . 14 . 4368–76 . 2004 . 15314207 . 10.1093/nar/gkh754 . 514376 . vanc. Kristensen MA . Willemoës M . 3 . Nielsen . FC . Christiansen . J .
• Suzuki Y . Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions . Genome Res. . 14 . 9 . 1711–8 . 2004 . 15342556 . 10.1101/gr.2435604 . 515316 . vanc. Yamashita R . Shirota M . 3 . Sakakibara . Y . Chiba . J . Mizushima-Sugano . J . Nakai . K . Sugano . S .
• Liao B . Targeted knockdown of the RNA-binding protein CRD-BP promotes cell proliferation via an insulin-like growth factor II-dependent pathway in human K562 leukemia cells . J. Biol. Chem. . 279 . 47 . 48716–24 . 2005 . 15355996 . 10.1074/jbc.M405853200 . vanc. Patel M . Hu Y . 3 . Charles . S . Herrick . DJ . Brewer . G . free.

Notes and References

1. Nielsen J, Christiansen J, Lykke-Andersen J, Johnsen AH, Wewer UM, Nielsen FC . A Family of Insulin-Like Growth Factor II mRNA-Binding Proteins Represses Translation in Late Development . Mol Cell Biol . 19 . 2 . 1262–70 . Feb 1999 . 9891060 . 116055 . 10.1128/MCB.19.2.1262.
2. Yaniv K, Yisraeli JK . The involvement of a conserved family of RNA binding proteins in embryonic development and carcinogenesis . Gene . 287 . 1–2 . 49–54 . May 2002 . 11992722 . 10.1016/S0378-1119(01)00866-6 .
3. Web site: Entrez Gene: IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1.