Hyperprothrombinemia Explained

Hyperprothrombinemia is a state of high of prothrombin levels in the blood^[1] which leads to hypercoagulability. An example of a genetic cause includes the mutation prothrombin G20210A.^[2] Hyperprothrombinemia is a risk factor for venous thromboembolism.

See also

• Blood coagulation

Further reading

• Colucci . Mario . Binetti . Bianca M. . Tripodi . Armando . Chantarangkul . Veena . Semeraro . Nicola . Hyperprothrombinemia associated with prothrombin G20210A mutation inhibits plasma fibrinolysis through a TAFI-mediated mechanism . Blood . American Society of Hematology . 103 . 6 . March 15, 2004 . 0006-4971 . 10.1182/blood-2003-06-2169 . 2157–2161 . free . 14630828 . none.
• CASTOLDI . E. . SIMIONI . P. . TORMENE . D. . THOMASSEN . M.C.L.G.D. . SPIEZIA . L. . GAVASSO . S. . ROSING . J. . Differential effects of high prothrombin levels on thrombin generation depending on the cause of the hyperprothrombinemia . Journal of Thrombosis and Haemostasis . Elsevier BV . 5 . 5 . 2007 . 1538-7836 . 10.1111/j.1538-7836.2007.02448.x . 971–979 . 17461930 . none. free .

Notes and References

1. http://www.merriam-webster.com/medical/hyperprothrombinemia Hyperprothrombinemia
2. Tripodi A . Laboratory diagnosis of thrombophilic states: where do we stand? . Pathophysiol Haemost Thromb . 32 . 5–6 . 245–8 . 2002 . 13679650 . 10.1159/000073574 . free .