Hyaluronate lyase explained

The enzyme hyaluronate lyase catalyzes the chemical reaction

Cleaves hyaluronate chains at a β-D-GalNAc-(1→4)-β-D-GlcA bond, ultimately breaking the polysaccharide down to 3-(4-deoxy-β-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine

This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on polysaccharides. The systematic name of this enzyme class is hyaluronate lyase. Other names in common use include hyaluronidase (ambiguous), (hyalurononglucosaminidase) (ambiguous), (hyaluronoglucuronidase)], glucuronoglycosaminoglycan lyase, spreading factor, and mucinase (ambiguous).

Structural studies

As of late 2007, 27 structures have been solved for this class of enzymes, with PDB accession codes,,,,,,,,,,,,,,,,,,,,,,,,,, and .

References

• Linker A, Hoffman P, Meyer K, Sampson P, Korn ED . 1960 . The formation of unsaturated disaccharides from mucopoly-saccharides and their cleavage to alpha-keto acid by bacterial enzymes . Journal of Biological Chemistry . 235 . 11 . 3061–5 . 10.1016/S0021-9258(20)81309-X . free . 13762462 .
• Book: Meyer K, Rapport MM . Hyaluronidases . 1952 . Advances in Enzymology and Related Areas of Molecular Biology . Advances in Enzymology and Related Subjects of Biochemistry . Advances in Enzymology - and Related Areas of Molecular Biology . 13 . 199 - 236 . 10.1002/9780470122587.ch6 . 14943668 . 978-0-470-64614-4 .
• Moran F, Nasuno S, Starr MP . 1968 . Extracellular and intracellular polygalalacturonic acid trans-eliminases of Erwinia carotovora . Archives of Biochemistry and Biophysics . 123 . 298 - 306 . 5642600 . 10.1016/0003-9861(68)90138-0 . 2 .