Histamine glutarimide explained

Legal Status:	Investigational
Cas Number:	1464897-15-1
Pubchem:	24826317
Drugbank:	DB16016
Chemspiderid:	48673501
Unii:	VOM9DP10M3
Synonyms:	XC-8
Iupac Name:	1-[2-(1H-imidazol-5-yl)ethyl]piperidine-2,6-dione
C:	10
H:	13
N:	3
O:	2
Smiles:	C1CC(=O)N(C(=O)C1)CCC2=CN=CN2
Stdinchi:	1S/C10H13N3O2/c14-9-2-1-3-10(15)13(9)5-4-8-6-11-7-12-8/h6-7H,1-5H2,(H,11,12)
Stdinchikey:	DYKZYSKWOHKZMF-UHFFFAOYSA-N

Histamine glutarimide is an investigational new drug that is being evaluated for the treatment of cough in acute respiratory infection.^[1] It is a glutaminyl cyclase inhibitor.^[2]

Notes and References

Web site: Histamine glutarimide - EURRUS Biotech . AdisInsight . Springer Nature Switzerland AG .
Romanova J, Chikina E, Rydlovskaya A, Pohl W, Renner A, Zeifman A, Chuchalin A, Nebolsin V . New Anti-Chemokine Oral Drug XC8 in the Treatment of Asthma Patients with Poor Response to Corticosteroids: Results of a Phase 2A Randomized Controlled Clinical Trial . Pulmonary Therapy . 6 . 2 . 351–369 . December 2020 . 33095411 . 7671956 . 10.1007/s41030-020-00134-5 .