Hiroyuki Sasaki Explained
is a Japanese geneticist known for contributing to clarify epigenetic regulations during gametogenesis and embryogenesis through investigation of genomic imprinting as a model. He participates in the International Human Epigenome Consortium [IHEC].
Biography
Sasaki was born in Fukuoka, Japan in 1956, and received his MD and PhD in 1982 and 1987, respectively, from Kyushu University. He was appointed as a professor of the National Institute of Genetics in 1998. He has been a professor at the Medical Institute of Bioregulation, Kyushu University since 2010, where he has been serving as a dean since 2012. He has been a vice president of Kyushu University since 2015, and a dean of the Institute for Advanced Study, Kyushu University since 2018.
Awards
- 2009: The Japan Society of Human Genetics award
- 2012: Kihara Award of the Genetics Society of Japan
- 2015: Purple Ribbon Medal
References
- Sasaki H. Presymptomatic diagnosis of heterozygosity for familial amyloidotic polyneuropathy by recombinant DNA techniques. Lancet. 325. 8420. 100. 1985. etal. 10.1016/S0140-6736(85)91985-3. 2856994.
- Ferguson-Smith AC. Parental-origin-specific epigenetic modification of the mouse H19 gene. Nature. 362. 6422. 751–755. 1993. etal. 10.1038/362751a0. 8469285.
- Kaneda M. Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting. Nature. 429. 6994. 900–903. 2004. etal. 10.1038/nature02633. 15215868.
- Watanabe T. Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes. Nature. 453. 7194. 539–543. 2008. etal. 10.1038/nature06908. 18404146.
- Sasaki H and Matsui Y.. Epigenetic events in mammalian germ-cell development: reprogramming and beyond. Nat. Rev. Genet.. 9. 2. 129–140. 2008. 18197165. 10.1038/nrg2295.
- Watanabe T. Role for piRNAs and non-coding RNA in de novo DNA methylation of the imprinted mouse Rasgrf1 locus. Science . 332. 6031. 848–852. 2011. etal. 10.1126/science.1203919. 21566194. 3368507.
- Stunnenberg HG. The International Human Epigenome Consortium: a blueprint for scientific collaboration and discovery. Cell . 167. 5. 1145–1149. 2016. etal. 10.1016/j.cell.2016.11.007. 27863232. free.
- Yamashiro C. Generation of human oogonia from induced pluripotent stem cells in vitro. Science. 362. 6412. 356–360. 2018. etal. 10.1126/science.aat1674. 30237246. 2433/242826. free. free.
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