HSD17B8 explained

Estradiol 17 beta-dehydrogenase 8 is an enzyme that in humans is encoded by the HSD17B8 gene.^{[1] [2]}

In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically active estrogens and androgens. It is preferentially an oxidative enzyme and inactivates estradiol, testosterone, and dihydrotestosterone. However, the enzyme has some reductive activity and can synthesize estradiol from estrone. The protein encoded by this gene is similar to Ke6 and is a member of the short-chain dehydrogenase superfamily. An alternatively spliced transcript of this gene has been detected, but the full-length nature of this variant has not been determined.^[3]

Further reading

• Kikuti YY, Tamiya G, Ando A, etal . Physical mapping 220 kb centromeric of the human MHC and DNA sequence analysis of the 43-kb segment including the RING1, HKE6, and HKE4 genes . Genomics . 42 . 3 . 422–35 . 1997 . 9205114 . 10.1006/geno.1997.4745 .
• Fomitcheva J, Baker ME, Anderson E, etal . Characterization of Ke 6, a new 17beta-hydroxysteroid dehydrogenase, and its expression in gonadal tissues . J. Biol. Chem. . 273 . 35 . 22664–71 . 1998 . 9712896 . 10.1074/jbc.273.35.22664 . free .
• Hartley JL, Temple GF, Brasch MA . DNA Cloning Using In Vitro Site-Specific Recombination . Genome Res. . 10 . 11 . 1788–95 . 2001 . 11076863 . 10.1101/gr.143000 . 310948 .
• Aziz N, Anderson E, Lee GY, Woo DD . Arrested testis development in the cpk mouse may be the result of abnormal steroid metabolism . Mol. Cell. Endocrinol. . 171 . 1–2 . 83–8 . 2001 . 11165015 . 10.1016/S0303-7207(00)00390-7 . 20566396 .
• Kutsenko AS, Gizatullin RZ, Al-Amin AN, etal . NotI flanking sequences: a tool for gene discovery and verification of the human genome . Nucleic Acids Res. . 30 . 14 . 3163–70 . 2002 . 12136098 . 10.1093/nar/gkf428 . 135748 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Mungall AJ, Palmer SA, Sims SK, etal . The DNA sequence and analysis of human chromosome 6 . Nature . 425 . 6960 . 805–11 . 2003 . 14574404 . 10.1038/nature02055 . 2003Natur.425..805M . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Wiemann S, Arlt D, Huber W, etal . From ORFeome to Biology: A Functional Genomics Pipeline . Genome Res. . 14 . 10B . 2136–44 . 2004 . 15489336 . 10.1101/gr.2576704 . 528930 .
• Mehrle A, Rosenfelder H, Schupp I, etal . The LIFEdb database in 2006 . Nucleic Acids Res. . 34 . Database issue . D415–8 . 2006 . 16381901 . 10.1093/nar/gkj139 . 1347501 .
• Song D, Liu G, Luu-The V, etal . Expression of aromatase and 17beta-hydroxysteroid dehydrogenase types 1, 7 and 12 in breast cancer. An immunocytochemical study . J. Steroid Biochem. Mol. Biol. . 101 . 2–3 . 136–44 . 2006 . 16930994 . 10.1016/j.jsbmb.2006.06.015 . 27619774 .
• Villar J, Celay J, Alonso MM, etal . Transcriptional regulation of the human type 8 17beta-hydroxysteroid dehydrogenase gene by C/EBPbeta . J. Steroid Biochem. Mol. Biol. . 105 . 1–5 . 131–9 . 2007 . 17583490 . 10.1016/j.jsbmb.2006.12.106 . 54404567 .

Notes and References

1. Ando A, Kikuti YY, Shigenari A, Kawata H, Okamoto N, Shiina T, Chen L, Ikemura T, Abe K, Kimura M, Inoko H . cDNA cloning of the human homologues of the mouse Ke4 and Ke6 genes at the centromeric end of the human MHC region . Genomics . 35 . 3 . 600–2 . Dec 1996 . 8812499 . 10.1006/geno.1996.0405 .
2. Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U . The SDR (Short-Chain Dehydrogenase/Reductase and Related Enzymes) Nomenclature Initiative . Chem Biol Interact . 178 . 1–3 . 94–8 . Feb 2009 . 19027726 . 2896744. 10.1016/j.cbi.2008.10.040 . 2009CBI...178...94P .
3. Web site: Entrez Gene: HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8.