HSD17B6 explained

Hydroxysteroid 17-beta dehydrogenase 6 is an enzyme that in humans is encoded by the HSD17B6 gene.^{[1] [2] [3]}

The protein encoded by this gene has both oxidoreductase and epimerase activities and is involved in androgen catabolism. The oxidoreductase activity can convert 3 alpha-adiol to dihydrotestosterone, while the epimerase activity can convert androsterone to epi-androsterone. Both reactions use NAD+ as the preferred cofactor. This gene is a member of the retinol dehydrogenase family. Transcript variants utilizing alternative polyadenylation signals exist.

Further reading

• Biswas MG, Russell DW . Expression cloning and characterization of oxidative 17beta- and 3alpha-hydroxysteroid dehydrogenases from rat and human prostate . J. Biol. Chem. . 272 . 25 . 15959–66 . 1997 . 9188497 . 10.1074/jbc.272.25.15959 . free .
• Huang XF, Luu-The V . Molecular characterization of a first human 3(alpha-->beta)-hydroxysteroid epimerase . J. Biol. Chem. . 275 . 38 . 29452–7 . 2000 . 10896656 . 10.1074/jbc.M000562200 . free .
• Kedishvili NY, Belyaeva OV, Gough WH . Cloning of the human RoDH-related short chain dehydrogenase gene and analysis of its structure . Chem. Biol. Interact. . 130-132 . 1–3 . 457–67 . 2001 . 11306067 . 10.1016/S0009-2797(00)00291-X .
• Chetyrkin SV, Hu J, Gough WH, etal . Further characterization of human microsomal 3alpha-hydroxysteroid dehydrogenase . Arch. Biochem. Biophys. . 386 . 1 . 1–10 . 2001 . 11360992 . 10.1006/abbi.2000.2203 .
• Huang XF, Luu-The V . Gene structure, chromosomal localization and analysis of 3-ketosteroid reductase activity of the human 3(alpha-->beta)-hydroxysteroid epimerase . Biochim. Biophys. Acta . 1520 . 2 . 124–30 . 2001 . 11513953 . 10.1016/s0167-4781(01)00247-0.
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Jones MR, Italiano L, Wilson SG, etal . Polymorphism in HSD17B6 is associated with key features of polycystic ovary syndrome . Fertil. Steril. . 86 . 5 . 1438–46 . 2006 . 17070195 . 10.1016/j.fertnstert.2006.04.027 . free .
• Belyaeva OV, Chetyrkin SV, Clark AL, etal . Role of microsomal retinol/sterol dehydrogenase-like short-chain dehydrogenases/reductases in the oxidation and epimerization of 3alpha-hydroxysteroids in human tissues . Endocrinology . 148 . 5 . 2148–56 . 2007 . 17289849 . 10.1210/en.2006-1491 . 2571913 .

Notes and References

1. Baker ME . Evolution of 17beta-hydroxysteroid dehydrogenases and their role in androgen, estrogen and retinoid action . Mol Cell Endocrinol . 171 . 1–2 . 211–5 . Feb 2001 . 11165032 . 10.1016/S0303-7207(00)00414-7 . 42947381 .
2. Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U . The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative . Chem Biol Interact . 178 . 1–3 . 94–8 . Feb 2009 . 19027726 . 2896744. 10.1016/j.cbi.2008.10.040 . 2009CBI...178...94P .
3. Web site: Entrez Gene: HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6 homolog (mouse).