HOXB4 explained

Homeobox protein Hox-B4 is a protein that in humans is encoded by the HOXB4 gene.^{[1] [2] [3]}

Function

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion.

See also

• Homeobox

Further reading

• Petrini M, Quaranta MT, Testa U, Samoggia P, Tritarelli E, Carè A, Cianetti L, Valtieri M, Barletta C, Peschle C . Expression of selected human HOX-2 genes in B/T acute lymphoid leukemia and interleukin-2/interleukin-1 beta-stimulated natural killer lymphocytes . Blood . 80 . 1 . 185–93 . Jul 1992 . 1351762 . 10.1182/blood.V80.1.185.185. free .
• Peverali FA, D'Esposito M, Acampora D, Bunone G, Negri M, Faiella A, Stornaiuolo A, Pannese M, Migliaccio E, Simeone A . Expression of HOX homeogenes in human neuroblastoma cell culture lines . Differentiation; Research in Biological Diversity . 45 . 1 . 61–9 . Oct 1990 . 1981366 . 10.1111/j.1432-0436.1990.tb00458.x .
• Giampaolo A, Acampora D, Zappavigna V, Pannese M, D'Esposito M, Carè A, Faiella A, Stornaiuolo A, Russo G, Simeone A . Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system . Differentiation; Research in Biological Diversity . 40 . 3 . 191–7 . Jun 1989 . 2570724 . 10.1111/j.1432-0436.1989.tb00598.x .
• Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E . The human HOX gene family . Nucleic Acids Research . 17 . 24 . 10385–402 . Dec 1989 . 2574852 . 335308 . 10.1093/nar/17.24.10385 .
• Boncinelli E, Acampora D, Pannese M, D'Esposito M, Somma R, Gaudino G, Stornaiuolo A, Cafiero M, Faiella A, Simeone A . Organization of human class I homeobox genes . Genome . 31 . 2 . 745–56 . 1990 . 2576652 . 10.1139/g89-133 .
• Kuliev A, Kukharenko V, Morozov G, Freidine M, Rechitsky S, Verlinsky O, Ivakhnenko V, Gindilis V, Strom C, Verlinsky Y . Expression of homebox-containing genes in human preimplantation development and in embryos with chromosomal aneuploidies . Journal of Assisted Reproduction and Genetics . 13 . 2 . 177–81 . Feb 1996 . 8688592 . 10.1007/BF02072541 . 28126784 .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Research . 6 . 9 . 791–806 . Sep 1996 . 8889548 . 10.1101/gr.6.9.791 . free .
• Bodey B, Bodey B, Siegel SE, Kaiser HE . Immunocytochemical detection of the homeobox B3, B4, and C6 gene products within the human thymic cellular microenvironment . In Vivo . 14 . 3 . 419–24 . 2000 . 10904875 .
• Giannola DM, Shlomchik WD, Jegathesan M, Liebowitz D, Abrams CS, Kadesch T, Dancis A, Emerson SG . Hematopoietic expression of HOXB4 is regulated in normal and leukemic stem cells through transcriptional activation of the HOXB4 promoter by upstream stimulating factor (USF)-1 and USF-2 . The Journal of Experimental Medicine . 192 . 10 . 1479–90 . Nov 2000 . 11085749 . 2193192 . 10.1084/jem.192.10.1479 .
• Pan Q, Simpson RU . Antisense knockout of HOXB4 blocks 1,25-dihydroxyvitamin D3 inhibition of c-myc expression . The Journal of Endocrinology . 169 . 1 . 153–9 . Apr 2001 . 11250656 . 10.1677/joe.0.1690153 . free .
• Shen WF, Krishnan K, Lawrence HJ, Largman C . The HOX homeodomain proteins block CBP histone acetyltransferase activity . Molecular and Cellular Biology . 21 . 21 . 7509–22 . Nov 2001 . 11585930 . 99922 . 10.1128/MCB.21.21.7509-7522.2001 .
• Kömüves LG, Michael E, Arbeit JM, Ma XK, Kwong A, Stelnicki E, Rozenfeld S, Morimune M, Yu QC, Largman C . HOXB4 homeodomain protein is expressed in developing epidermis and skin disorders and modulates keratinocyte proliferation . Developmental Dynamics . 224 . 1 . 58–68 . May 2002 . 11984874 . 10.1002/dvdy.10085 . 19816254 . free .
• Buske C, Feuring-Buske M, Abramovich C, Spiekermann K, Eaves CJ, Coulombel L, Sauvageau G, Hogge DE, Humphries RK . Deregulated expression of HOXB4 enhances the primitive growth activity of human hematopoietic cells . Blood . 100 . 3 . 862–8 . Aug 2002 . 12130496 . 10.1182/blood-2002-01-0220 . free .
• Schiedlmeier B, Klump H, Will E, Arman-Kalcek G, Li Z, Wang Z, Rimek A, Friel J, Baum C, Ostertag W . High-level ectopic HOXB4 expression confers a profound in vivo competitive growth advantage on human cord blood CD34+ cells, but impairs lymphomyeloid differentiation . Blood . 101 . 5 . 1759–68 . Mar 2003 . 12406897 . 10.1182/blood-2002-03-0767 . free .
• Theokli C, Morsi El-Kadi AS, Morgan R . TALE class homeodomain gene Irx5 is an immediate downstream target for Hoxb4 transcriptional regulation . Developmental Dynamics . 227 . 1 . 48–55 . May 2003 . 12701098 . 10.1002/dvdy.10287 . 10293029 .
• Kömüves LG, Ma XK, Stelnicki E, Rozenfeld S, Oda Y, Largman C . HOXB13 homeodomain protein is cytoplasmic throughout fetal skin development . Developmental Dynamics . 227 . 2 . 192–202 . Jun 2003 . 12761847 . 10.1002/dvdy.10290 . 42243036 .
• Zhu J, Giannola DM, Zhang Y, Rivera AJ, Emerson SG . NF-Y cooperates with USF1/2 to induce the hematopoietic expression of HOXB4 . Blood . 102 . 7 . 2420–7 . Oct 2003 . 12791656 . 10.1182/blood-2003-01-0251 . free .

Notes and References

1. McAlpine PJ, Shows TB . Nomenclature for human homeobox genes . Genomics . 7 . 3 . 460 . Jul 1990 . 1973146 . 10.1016/0888-7543(90)90186-X .
2. Scott MP . Vertebrate homeobox gene nomenclature . Cell . 71 . 4 . 551–3 . Nov 1992 . 1358459 . 10.1016/0092-8674(92)90588-4 . 13370372 .
3. Web site: Entrez Gene: HOXB4 homeobox B4.