HORMA domain explained

In molecular biology, the HORMA domain (named after the Hop1p, Rev7p and MAD2 proteins) is a protein domain that has been suggested to recognise chromatin states resulting from DNA adducts, double stranded breaks or non-attachment to the spindle and act as an adaptor that recruits other proteins. Hop1 is a meiosis-specific protein, Rev7 is required for DNA damage induced mutagenesis, and MAD2 is a spindle checkpoint protein which prevents progression of the cell cycle upon detection of a defect in mitotic spindle integrity.^{[1] [2]}

Examples

Humans proteins containing this domain include:

• HORMAD1, HORMAD2, MAD2L1, MAD2L2

Notes and References

1. He X, Patterson TE, Sazer S . The Schizosaccharomyces pombe spindle checkpoint protein mad2p blocks anaphase and genetically interacts with the anaphase-promoting complex. . Proc Natl Acad Sci U S A . 1997 . 94 . 15 . 7965–70 . 9223296 . 10.1073/pnas.94.15.7965. 21538 . 1997PNAS...94.7965H . free .
2. Aravind L, Koonin EV . The HORMA domain: a common structural denominator in mitotic checkpoints, chromosome synapsis and DNA repair. . Trends Biochem Sci . 1998 . 23 . 8 . 284–6 . 9757827 . 10.1016/S0968-0004(98)01257-2.