See also: History and naming of human leukocyte antigens.
| Isoformgroup: | HLA-A23 |
| Polymer Type: | MHC Class I, A cell surface antigen |
| Protein Type: | transmembrane receptor/ligand |
| Structure: | αβ heterodimer |
| Subunit Genes: | HLA-A
|
| Linkout: | HAwA |
| Alias: | HL-A9 |
| Isoformcount: | 1 |
| Subunit1: | allele |
| Nick1: | A23 |
| Allele1a: | 2301 |
HLA-A23 (A23) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α23 subset of HLA-A α-chains. For A23, the alpha, "A", chain are encoded by the HLA-A allele group and the β-chain are encoded by B2M locus.[1] This group currently is dominated by A*2301. A23 and A are almost synonymous in meaning.A23 is a split antigen of the broad antigen HLA-A9 and it is a sister serotype of HLA-A24.
A23 is common in Africa and regions of the Middle East, Mediterranean, and India than Europe, East Asia or the Americas.
A23-B7 is found in N.Afr. and S.Afr non-caucasians.
A23-B44 is found in Albania, Zimbabwe, Morocco, Spain and Danes.
A23-B58 is found in the !kung and Zaire.
A*23:Cw*07 is associated with higher viral load in HIV[2]