HIST3H2BB explained

Histone H2B type 3-B is a protein that in humans is encoded by the HIST3H2BB gene.^{[1] [2]}

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 base pairs (bp) of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene contain a palindromic termination element.^[2]

Further reading

• Borowski P, Heiland M, Oehlmann K, etal . Non-structural protein 3 of hepatitis C virus inhibits phosphorylation mediated by cAMP-dependent protein kinase. . Eur. J. Biochem. . 237 . 3 . 611–8 . 1996 . 8647104 . 10.1111/j.1432-1033.1996.0611p.x . free .
• El Kharroubi A, Piras G, Zensen R, Martin MA . Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter. . Mol. Cell. Biol. . 18 . 5 . 2535–44 . 1998 . 9566873 . 10.1128/mcb.18.5.2535. 110633 .
• Borowski P, Kühl R, Laufs R, etal . Identification and characterization of a histone binding site of the non-structural protein 3 of hepatitis C virus. . J. Clin. Virol. . 13 . 1–2 . 61–9 . 1999 . 10405893 . 10.1016/S1386-6532(99)00007-4 .
• Thomson S, Clayton AL, Hazzalin CA, etal . The nucleosomal response associated with immediate-early gene induction is mediated via alternative MAP kinase cascades: MSK1 as a potential histone H3/HMG-14 kinase. . EMBO J. . 18 . 17 . 4779–93 . 1999 . 10469656 . 10.1093/emboj/18.17.4779 . 1171550 .
• Deng L, de la Fuente C, Fu P, etal . Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones. . Virology . 277 . 2 . 278–95 . 2001 . 11080476 . 10.1006/viro.2000.0593 . free .
• Deng L, Wang D, de la Fuente C, etal . Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA. . Virology . 289 . 2 . 312–26 . 2001 . 11689053 . 10.1006/viro.2001.1129 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Cheung WL, Ajiro K, Samejima K, etal . Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. . Cell . 113 . 4 . 507–17 . 2003 . 12757711 . 10.1016/S0092-8674(03)00355-6 . 21854 . free .
• Coleman MA, Miller KA, Beernink PT, etal . Identification of chromatin-related protein interactions using protein microarrays. . Proteomics . 3 . 11 . 2101–7 . 2004 . 14595808 . 10.1002/pmic.200300593 . 23471253 .
• Lusic M, Marcello A, Cereseto A, Giacca M . Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter. . EMBO J. . 22 . 24 . 6550–61 . 2004 . 14657027 . 10.1093/emboj/cdg631 . 291826 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Kanno T, Kanno Y, Siegel RM, etal . Selective recognition of acetylated histones by bromodomain proteins visualized in living cells. . Mol. Cell . 13 . 1 . 33–43 . 2004 . 14731392 . 10.1016/S1097-2765(03)00482-9 . free .
• Zhang Y, Griffin K, Mondal N, Parvin JD . Phosphorylation of histone H2A inhibits transcription on chromatin templates. . J. Biol. Chem. . 279 . 21 . 21866–72 . 2004 . 15010469 . 10.1074/jbc.M400099200 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Golebiowski F, Kasprzak KS . Inhibition of core histones acetylation by carcinogenic nickel(II). . Mol. Cell. Biochem. . 279 . 1–2 . 133–9 . 2007 . 16283522 . 10.1007/s11010-005-8285-1 . 25071586 .
• Zhu B, Zheng Y, Pham AD, etal . Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. . Mol. Cell . 20 . 4 . 601–11 . 2006 . 16307923 . 10.1016/j.molcel.2005.09.025 . free .
• Bonenfant D, Coulot M, Towbin H, etal . Characterization of histone H2A and H2B variants and their post-translational modifications by mass spectrometry. . Mol. Cell. Proteomics . 5 . 3 . 541–52 . 2006 . 16319397 . 10.1074/mcp.M500288-MCP200 . free .
• Beck HC, Nielsen EC, Matthiesen R, etal . Quantitative proteomic analysis of post-translational modifications of human histones. . Mol. Cell. Proteomics . 5 . 7 . 1314–25 . 2006 . 16627869 . 10.1074/mcp.M600007-MCP200 . free .
• Gregory SG, Barlow KF, McLay KE, etal . The DNA sequence and biological annotation of human chromosome 1. . Nature . 441 . 7091 . 315–21 . 2006 . 16710414 . 10.1038/nature04727 . 2006Natur.441..315G . free .

Notes and References

1. Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ . The human and mouse replication-dependent histone genes . Genomics . 80 . 5 . 487–98 . Oct 2002 . 12408966 . 10.1016/S0888-7543(02)96850-3 .
2. Web site: Entrez Gene: HIST3H2BB histone cluster 3, H2bb.