HIST1H2BK explained

Histone H2B type 1-K is a protein that in humans is encoded by the HIST1H2BK gene.^{[1] [2]}

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the histone H2B family. This gene is found in the histone microcluster on chromosome 6p21.33.

Interactions

HIST1H2BK has been shown to interact with HIRA.^[3]

Further reading

• Dobner T, Wolf I, Mai B, Lipp M . A novel divergently transcribed human histone H2A/H2B gene pair . DNA Seq. . 1 . 6 . 409–13 . 1992 . 1768865 . 10.3109/10425179109020799 .
• Frohm M . Biochemical and antibacterial analysis of human wound and blister fluid . Eur. J. Biochem. . 237 . 1 . 86–92 . 1996 . 8620898 . 10.1111/j.1432-1033.1996.0086n.x . vanc. Gunne H . Bergman AC . 3 . Agerberth . Birgitta . Bergman . Tomas . Boman . Anita . Liden . Sture . Jornvall . Hans . Boman . Hans G. . free .
• El Kharroubi A, Piras G, Zensen R, Martin MA . Transcriptional Activation of the Integrated Chromatin-Associated Human Immunodeficiency Virus Type 1 Promoter . Mol. Cell. Biol. . 18 . 5 . 2535–44 . 1998 . 9566873 . 10.1128/mcb.18.5.2535. 110633 .
• Lorain S . Core Histones and HIRIP3, a Novel Histone-Binding Protein, Directly Interact with WD Repeat Protein HIRA . Mol. Cell. Biol. . 18 . 9 . 5546–56 . 1998 . 9710638 . 10.1128/MCB.18.9.5546. 109139 . vanc. Quivy JP . Monier-Gavelle F . 3 . Scamps . C . Lécluse . Y . Almouzni . G . Lipinski . M .
• Albig W . The human H2A and H2B histone gene complement . Biol. Chem. . 380 . 1 . 7–18 . 1999 . 10064132 . 10.1515/BC.1999.002 . vanc. Trappe R . Kardalinou E . 3 . Eick . S. . Doenecke . D. . 12807248 .
• Ahn J, Gruen JR . The genomic organization of the histone clusters on human 6p21.3 . Mamm. Genome . 10 . 7 . 768–70 . 1999 . 10384058 . 10.1007/s003359901089 . 28275496 .
• Deng L . Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones . Virology . 277 . 2 . 278–95 . 2001 . 11080476 . 10.1006/viro.2000.0593 . vanc. de la Fuente C . Fu P . 3 . Wang . L . Donnelly . R . Wade . JD . Lambert . P . Li . H . Lee . CG . free .
• Deng L . Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA . Virology . 289 . 2 . 312–26 . 2001 . 11689053 . 10.1006/viro.2001.1129 . vanc. Wang D . de la Fuente C . 3 . Wang . L . Li . H . Lee . CG . Donnelly . R . Wade . JD . Lambert . P . free .
• Kim HS . Endotoxin-neutralizing antimicrobial proteins of the human placenta . J. Immunol. . 168 . 5 . 2356–64 . 2002 . 11859126 . 10.4049/jimmunol.168.5.2356. vanc. Cho JH . Park HW . 3 . Yoon . H . Kim . MS . Kim . SC . free.
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M. free .
• Cheung WL . Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase . Cell . 113 . 4 . 507–17 . 2003 . 12757711 . 10.1016/S0092-8674(03)00355-6 . vanc. Ajiro K . Samejima K . 3 . Kloc . Malgorzata . Cheung . Peter . Mizzen . Craig A. . Beeser . Alexander . Etkin . Laurence D. . Chernoff . Jonathan . 21854 . free .
• Tollin M . Antimicrobial peptides in the first line defence of human colon mucosa . Peptides . 24 . 4 . 523–30 . 2004 . 12860195 . 10.1016/S0196-9781(03)00114-1 . vanc. Bergman P . Svenberg T . 3 . Jörnvall . Hans . Gudmundsson . Gudmundur Hrafn . Agerberth . Birgitta . 7435936 .
• Mungall AJ . The DNA sequence and analysis of human chromosome 6 . Nature . 425 . 6960 . 805–11 . 2003 . 14574404 . 10.1038/nature02055 . vanc. Palmer SA . Sims SK . 3 . Edwards . C. A. . Ashurst . J. L. . Wilming . L. . Jones . M. C. . Horton . R. . Hunt . S. E. . free . 2003Natur.425..805M .
• Lusic M, Marcello A, Cereseto A, Giacca M . Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter . EMBO J. . 22 . 24 . 6550–61 . 2004 . 14657027 . 10.1093/emboj/cdg631 . 291826 .
• Howell SJ, Wilk D, Yadav SP, Bevins CL . Antimicrobial polypeptides of the human colonic epithelium . Peptides . 24 . 11 . 1763–70 . 2004 . 15019208 . 10.1016/j.peptides.2003.07.028 . 28953527 .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Andersen JS . Nucleolar proteome dynamics . Nature . 433 . 7021 . 77–83 . 2005 . 15635413 . 10.1038/nature03207 . vanc. Lam YW . Leung AK . 3 . Ong . Shao-En . Lyon . Carol E. . Lamond . Angus I. . Mann . Matthias . 2005Natur.433...77A. 4344740 .
• Tsunaka Y, Kajimura N, Tate S, Morikawa K . Alteration of the nucleosomal DNA path in the crystal structure of a human nucleosome core particle . Nucleic Acids Res. . 33 . 10 . 3424–34 . 2005 . 15951514 . 10.1093/nar/gki663 . 1150222 .
• Golebiowski F, Kasprzak KS . Inhibition of core histones acetylation by carcinogenic nickel(II) . Mol. Cell. Biochem. . 279 . 1–2 . 133–9 . 2007 . 16283522 . 10.1007/s11010-005-8285-1 . 25071586 .

Notes and References

1. Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ . The human and mouse replication-dependent histone genes . Genomics . 80 . 5 . 487–98 . Oct 2002 . 12408966 . 10.1016/S0888-7543(02)96850-3 .
2. Web site: Entrez Gene: HIST1H2BK histone cluster 1, H2bk.
3. Lorain . S . Quivy J P . Monier-Gavelle F . Scamps C . Lécluse Y . Almouzni G . Lipinski M . Sep 1998 . Core Histones and HIRIP3, a Novel Histone-Binding Protein, Directly Interact with WD Repeat Protein HIRA . Mol. Cell. Biol. . 18 . 9 . 5546–56 . UNITED STATES. 0270-7306. 9710638 . 109139 . 10.1128/MCB.18.9.5546 .