HES6 explained

Transcription cofactor HES-6 is a protein that in humans is encoded by the HES6 gene.^{[1] [2]}

Interactions

HES6 has been shown to interact with TLE1.^[3]

Further reading

• Bech P, Bolwig TG, Dein E, Jacobsen O, Gram LF . Quantitative rating of manic states. Correlation between clinical assessment and Biegel's Objective Rating Scale . . 52 . 1 . 1–6 . 1975 . 1155198 . 10.1111/j.1600-0447.1975.tb00017.x . 7793095 .
• Vasiliauskas D, Stern CD . Expression of mouse HES-6, a new member of the Hairy/Enhancer of split family of bHLH transcription factors . Mech. Dev. . 98 . 1–2 . 133–7 . 2000 . 11044617 . 10.1016/S0925-4773(00)00443-3 . 15528953 . free .
• Gao X, Chandra T, Gratton MO, Quélo I, Prud'homme J, Stifani S, St-Arnaud R . HES6 acts as a transcriptional repressor in myoblasts and can induce the myogenic differentiation program . J. Cell Biol. . 154 . 6 . 1161–71 . 2001 . 11551980 . 2150829 . 10.1083/jcb.200104058 .
• Swearingen ML, Sun D, Bourner M, Weinstein EJ . Detection of differentially expressed HES-6 gene in metastatic colon carcinoma by combination of suppression subtractive hybridization and cDNA library array . Cancer Lett. . 198 . 2 . 229–39 . 2003 . 12957362 . 10.1016/S0304-3835(03)00313-6 .
• Gratton MO, Torban E, Jasmin SB, Theriault FM, German MS, Stifani S . Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription repression activity by multiple mechanisms . Mol. Cell. Biol. . 23 . 19 . 6922–35 . 2003 . 12972610 . 193938 . 10.1128/MCB.23.19.6922-6935.2003 .
• Kang SA, Seol JH, Kim J . The conserved WRPW motif of Hes6 mediates proteasomal degradation . Biochem. Biophys. Res. Commun. . 332 . 1 . 33–6 . 2005 . 15896295 . 10.1016/j.bbrc.2005.04.089 .
• Ball AJ, Abrahamsson AE, Tyrberg B, Itkin-Ansari P, Levine F . HES6 reverses nuclear reprogramming of insulin-producing cells following cell fusion . Biochem. Biophys. Res. Commun. . 355 . 2 . 331–7 . 2007 . 17300753 . 1852427 . 10.1016/j.bbrc.2007.01.153 .
• Carey KA, Farnfield MM, Tarquinio SD, Cameron-Smith D . Impaired expression of Notch signaling genes in aged human skeletal muscle . J. Gerontol. A Biol. Sci. Med. Sci. . 62 . 1 . 9–17 . 2007 . 17301032 . 10.1093/gerona/62.1.9 . 10.1.1.499.7911 .
• Scheffer D, Sage C, Corey DP, Pingault V . Gene expression profiling identifies Hes6 as a transcriptional target of ATOH1 in cochlear hair cells . FEBS Lett. . 581 . 24 . 4651–6 . 2007 . 17826772 . 10.1016/j.febslet.2007.08.059 . 13986512 . free . 2007FEBSL.581.4651S .

Notes and References

1. Bae S, Bessho Y, Hojo M, Kageyama R . The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation . Development . 127 . 13 . 2933–43 . Aug 2000 . 10.1242/dev.127.13.2933 . 10851137 .
2. Web site: Entrez Gene: HES6 hairy and enhancer of split 6 (Drosophila).
3. Gao X, Chandra T, Gratton MO, Quélo I, Prud'homme J, Stifani S, St-Arnaud R . HES6 acts as a transcriptional repressor in myoblasts and can induce the myogenic differentiation program . J. Cell Biol. . 154 . 6 . 1161–71 . Sep 2001 . 11551980 . 2150829 . 10.1083/jcb.200104058 .