HEC96719 explained
| Legal Status: | Investigational |
| Cas Number: | 2181834-03-5 |
| Pubchem: | 138675487 |
| Chembl: | 5171962 |
| Chemspiderid: | 129200607 |
| Iupac Name: | 3-5-Cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-ylmethoxy]spiro[6''H''-[1]benzoxepino[3,2-''b'']pyridine-5,1'-cyclopropane]-9-carboxylic acid |
| C: | 29 |
| H: | 22 |
| Cl: | 2 |
| N: | 2 |
| O: | 5 |
| Stdinchi: | 1S/C29H22Cl2N2O5/c30-19-2-1-3-20(31)24(19)25-18(26(38-33-25)15-4-5-15)14-36-23-9-8-21-27(32-23)29(10-11-29)13-17-7-6-16(28(34)35)12-22(17)37-21/h1-3,6-9,12,15H,4-5,10-11,13-14H2,(H,34,35) |
| Stdinchikey: | JZJOXLSYULKNLW-UHFFFAOYSA-N |
| Smiles: | C1CC1C2=C(C(=NO2)C3=C(C=CC=C3Cl)Cl)COC4=NC5=C(C=C4)OC6=C(CC57CC7)C=CC(=C6)C(=O)O |
HEC96719 is a tricyclic farnesoid X receptor agonist developed for non-alcoholic steatohepatitis.[1] [2] [3]
Notes and References
- Cao . Shengtian . Yang . Xinye . Zhang . Zheng . Wu . Junwen . Chi . Bo . Chen . Hong . Yu . Jianghong . Feng . Shanshan . Xu . Yulin . Li . Jing . Zhang . Yingjun . Wang . Xiaojun . Wang . Yan . Discovery of a tricyclic farnesoid X receptor agonist HEC96719, a clinical candidate for treatment of non-alcoholic steatohepatitis . European Journal of Medicinal Chemistry . February 2022 . 230 . 114089 . 10.1016/j.ejmech.2021.114089. 34998040 . 245577605 .
- Zhang . Na . Fan . Tianyun . Zhao . Liping . Li . Yiming . Bao . Yunyang . Ma . Xican . Mei . Yuheng . Wang . Yanxiang . Liu . Yonghua . Deng . Hongbin . Li . Yinghong . He . Hongwei . Song . Danqing . Discovery and development of palmatine analogues as anti-NASH agents by activating farnesoid X receptor (FXR) . European Journal of Medicinal Chemistry . January 2023 . 245 . Pt 1 . 114886 . 10.1016/j.ejmech.2022.114886. 36347091 . 253329947 .
- Lu . Ran . Liu . Ye . Hong . Tianpei . Epidemiological characteristics and management of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis in China: A narrative review . Diabetes, Obesity and Metabolism . April 2023 . 25 . S1 . 13–26 . 10.1111/dom.15014. 36775938 . 256825486 .
