HIST2H3A explained

Histone cluster 2 H3 family member a is a protein that in humans is encoded by the HIST2H3A gene.^[1]

Function

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on human chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy. [provided by RefSeq, Aug 2015].

Further reading

• Ruthenburg AJ, Wang W, Graybosch DM, Li H, Allis CD, Patel DJ, Verdine GL . Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex . Nat. Struct. Mol. Biol. . 13 . 8 . 704–12 . August 2006 . 16829959 . 4698793 . 10.1038/nsmb1119 .
• Couture JF, Collazo E, Trievel RC . Molecular recognition of histone H3 by the WD40 protein WDR5 . Nat. Struct. Mol. Biol. . 13 . 8 . 698–703 . August 2006 . 16829960 . 10.1038/nsmb1116 . 26165068 .
• Rodriguez-Collazo P, Snyder SK, Chiffer RC, Zlatanova J, Leuba SH, Smith CL . cAMP signaling induces rapid loss of histone H3 phosphorylation in mammary adenocarcinoma-derived cell lines . Exp. Cell Res. . 314 . 1 . 1–10 . January 2008 . 17950276 . 4426871 . 10.1016/j.yexcr.2007.09.011 .
• Ho CC, Cheng CC, Liu YH, Pei RJ, Hsu YH, Yeh KT, Ho LC, Tsai MC, Lai YS . Possible relation between histone 3 and cytokeratin 18 in human hepatocellular carcinoma . In Vivo . 22 . 4 . 457–62 . 2008 . 18712172 .
• Song JJ, Kingston RE . WDR5 interacts with mixed lineage leukemia (MLL) protein via the histone H3-binding pocket . J. Biol. Chem. . 283 . 50 . 35258–64 . December 2008 . 18840606 . 2596411 . 10.1074/jbc.M806900200 . free .
• Xie W, Song C, Young NL, Sperling AS, Xu F, Sridharan R, Conway AE, Garcia BA, Plath K, Clark AT, Grunstein M . Histone h3 lysine 56 acetylation is linked to the core transcriptional network in human embryonic stem cells . Mol. Cell . 33 . 4 . 417–27 . February 2009 . 19250903 . 2671231 . 10.1016/j.molcel.2009.02.004 .
• Loomis RJ, Naoe Y, Parker JB, Savic V, Bozovsky MR, Macfarlan T, Manley JL, Chakravarti D . Chromatin binding of SRp20 and ASF/SF2 and dissociation from mitotic chromosomes is modulated by histone H3 serine 10 phosphorylation . Mol. Cell . 33 . 4 . 450–61 . February 2009 . 19250906 . 2667802 . 10.1016/j.molcel.2009.02.003 .
• Suphioglu C, Sadli N, Coonan D, Kumar L, De Mel D, Lesheim J, Sinclair AJ, Ackland L . Zinc and DHA have opposing effects on the expression levels of histones H3 and H4 in human neuronal cells . Br. J. Nutr. . 103 . 3 . 344–51 . February 2010 . 19747413 . 10.1017/S0007114509991826 . free . 10536/DRO/DU:30023162 . free .

Notes and References

1. Web site: Entrez Gene: Histone cluster 2 H3 family member a. 2018-08-05.