H2BC12L explained

Histone H2B type F-S is a protein that in humans is encoded by the H2BC12L gene.^[1] It's a histone H2B isoform.

Further reading

• Frohm M, Gunne H, Bergman AC, Agerberth B, Bergman T, Boman A, Lidén S, Jörnvall H, Boman HG . Biochemical and antibacterial analysis of human wound and blister fluid . European Journal of Biochemistry . 237 . 1 . 86–92 . April 1996 . 8620898 . 10.1111/j.1432-1033.1996.0086n.x . free .
• El Kharroubi A, Piras G, Zensen R, Martin MA . Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter . Molecular and Cellular Biology . 18 . 5 . 2535–44 . May 1998 . 9566873 . 110633 . 10.1128/mcb.18.5.2535 .
• Deng L, de la Fuente C, Fu P, Wang L, Donnelly R, Wade JD, Lambert P, Li H, Lee CG, Kashanchi F . Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones . Virology . 277 . 2 . 278–95 . November 2000 . 11080476 . 10.1006/viro.2000.0593 . free .
• Deng L, Wang D, de la Fuente C, Wang L, Li H, Lee CG, Donnelly R, Wade JD, Lambert P, Kashanchi F . Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA . Virology . 289 . 2 . 312–26 . October 2001 . 11689053 . 10.1006/viro.2001.1129 . free .
• Kim HS, Cho JH, Park HW, Yoon H, Kim MS, Kim SC . Endotoxin-neutralizing antimicrobial proteins of the human placenta . Journal of Immunology . 168 . 5 . 2356–64 . March 2002 . 11859126 . 10.4049/jimmunol.168.5.2356 . free .
• Cheung WL, Ajiro K, Samejima K, Kloc M, Cheung P, Mizzen CA, Beeser A, Etkin LD, Chernoff J, Earnshaw WC, Allis CD . Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase . Cell . 113 . 4 . 507–17 . May 2003 . 12757711 . 10.1016/S0092-8674(03)00355-6 . 21854 . free .
• Tollin M, Bergman P, Svenberg T, Jörnvall H, Gudmundsson GH, Agerberth B . Antimicrobial peptides in the first line defence of human colon mucosa . Peptides . 24 . 4 . 523–30 . April 2003 . 12860195 . 10.1016/S0196-9781(03)00114-1 . 7435936 .
• Lusic M, Marcello A, Cereseto A, Giacca M . Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter . The EMBO Journal . 22 . 24 . 6550–61 . December 2003 . 14657027 . 291826 . 10.1093/emboj/cdg631 .
• Howell SJ, Wilk D, Yadav SP, Bevins CL . Antimicrobial polypeptides of the human colonic epithelium . Peptides . 24 . 11 . 1763–70 . November 2003 . 15019208 . 10.1016/j.peptides.2003.07.028 . 28953527 .
• Golebiowski F, Kasprzak KS . Inhibition of core histones acetylation by carcinogenic nickel(II) . Molecular and Cellular Biochemistry . 279 . 1–2 . 133–9 . November 2005 . 16283522 . 10.1007/s11010-005-8285-1 . 25071586 .
• Zhu B, Zheng Y, Pham AD, Mandal SS, Erdjument-Bromage H, Tempst P, Reinberg D . Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation . Molecular Cell . 20 . 4 . 601–11 . November 2005 . 16307923 . 10.1016/j.molcel.2005.09.025 . free .
• Beck HC, Nielsen EC, Matthiesen R, Jensen LH, Sehested M, Finn P, Grauslund M, Hansen AM, Jensen ON . Quantitative proteomic analysis of post-translational modifications of human histones . Molecular & Cellular Proteomics . 5 . 7 . 1314–25 . July 2006 . 16627869 . 10.1074/mcp.M600007-MCP200 . free .
• Pavri R, Zhu B, Li G, Trojer P, Mandal S, Shilatifard A, Reinberg D . Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II . Cell . 125 . 4 . 703–17 . May 2006 . 16713563 . 10.1016/j.cell.2006.04.029 . 2614680 . free .
• Kim SC, Sprung R, Chen Y, Xu Y, Ball H, Pei J, Cheng T, Kho Y, Xiao H, Xiao L, Grishin NV, White M, Yang XJ, Zhao Y . Substrate and functional diversity of lysine acetylation revealed by a proteomics survey . Molecular Cell . 23 . 4 . 607–18 . August 2006 . 16916647 . 10.1016/j.molcel.2006.06.026 . free .

Notes and References

1. Web site: Entrez Gene: H2BFS H2B histone family, member S.