HIST1H2BA explained

Histone H2B type 1-A is a protein that in humans is encoded by the HIST1H2BA gene.^{[1] [2] [3]}

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a testis/sperm-specific member of the histone H2B family. Transcripts from this gene contain a palindromic termination element.

Further reading

• El Kharroubi A, Piras G, Zensen R, Martin MA . Transcriptional Activation of the Integrated Chromatin-Associated Human Immunodeficiency Virus Type 1 Promoter . Mol. Cell. Biol. . 18 . 5 . 2535–44 . 1998 . 9566873 . 10.1128/mcb.18.5.2535. 110633 .
• Deng L, de la Fuente C, Fu P, etal . Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones . Virology . 277 . 2 . 278–95 . 2001 . 11080476 . 10.1006/viro.2000.0593 . free .
• Deng L, Wang D, de la Fuente C, etal . Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA . Virology . 289 . 2 . 312–26 . 2001 . 11689053 . 10.1006/viro.2001.1129 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Mungall AJ, Palmer SA, Sims SK, etal . The DNA sequence and analysis of human chromosome 6 . Nature . 425 . 6960 . 805–11 . 2003 . 14574404 . 10.1038/nature02055 . 2003Natur.425..805M . free .
• Lusic M, Marcello A, Cereseto A, Giacca M . Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter . EMBO J. . 22 . 24 . 6550–61 . 2004 . 14657027 . 10.1093/emboj/cdg631 . 291826 .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Li A, Maffey AH, Abbott WD, etal . Characterization of nucleosomes consisting of the human testis/sperm-specific histone H2B variant (hTSH2B) . Biochemistry . 44 . 7 . 2529–35 . 2005 . 15709765 . 10.1021/bi048061n .
• Golebiowski F, Kasprzak KS . Inhibition of core histones acetylation by carcinogenic nickel(II) . Mol. Cell. Biochem. . 279 . 1–2 . 133–9 . 2007 . 16283522 . 10.1007/s11010-005-8285-1 . 25071586 .
• Zhu B, Zheng Y, Pham AD, etal . Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation . Mol. Cell . 20 . 4 . 601–11 . 2006 . 16307923 . 10.1016/j.molcel.2005.09.025 . free .
• Pavri R, Zhu B, Li G, etal . Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II . Cell . 125 . 4 . 703–17 . 2006 . 16713563 . 10.1016/j.cell.2006.04.029 . 2614680 . free .
• Kim SC, Sprung R, Chen Y, etal . Substrate and functional diversity of lysine acetylation revealed by a proteomics survey . Mol. Cell . 23 . 4 . 607–18 . 2006 . 16916647 . 10.1016/j.molcel.2006.06.026 . free .

Notes and References

1. Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ . The human and mouse replication-dependent histone genes . Genomics . 80 . 5 . 487–98 . Oct 2002 . 12408966 . 10.1016/S0888-7543(02)96850-3 .
2. Zalensky AO, Siino JS, Gineitis AA, Zalenskaya IA, Tomilin NV, Yau P, Bradbury EM . Human testis/sperm-specific histone H2B (hTSH2B). Molecular cloning and characterization . J Biol Chem . 277 . 45 . 43474–80 . Nov 2002 . 12213818 . 10.1074/jbc.M206065200 . free .
3. Web site: Entrez Gene: HIST1H2BA histone cluster 1, H2ba.