H1FX explained

Histone H1x is a protein that in humans is encoded by the H1FX gene.^{[1] [2] [3]}

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H1 family.

Further reading

• Ohsumi K, Katagiri C . Occurrence of H1 subtypes specific to pronuclei and cleavage-stage cell nuclei of anuran amphibians . Dev. Biol. . 147 . 1 . 110–120 . 1991 . 1879604 . 10.1016/S0012-1606(05)80011-9 .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–16903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Sulimova GE . Human chromosome 3: integration of 60 NotI clones into a physical and gene map . Cytogenet. Genome Res. . 98 . 2–3 . 177–183 . 2003 . 12698000 . 10.1159/000069814 . vanc. Kutsenko AS . Rakhmanaliev ER . 3 . Udina . I.G. . Kompaniytsev . A.A. . Protopopov . A.I. . Moisjak . E.V. . Klimov . E.A. . Muravenko . O.V. . 41010053 .
• Beausoleil SA . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–12135 . 2004 . 15302935 . 10.1073/pnas.0404720101 . 514446 . vanc. Jedrychowski M . Schwartz D . 3 . Elias . JE . Villén . J . Li . J . Cohn . MA . Cantley . LC . Gygi . SP . 2004PNAS..10112130B . free .
• Gerhard DS . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–2127 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Garcia BA . Characterization of phosphorylation sites on histone H1 isoforms by tandem mass spectrometry . J. Proteome Res. . 3 . 6 . 1219–1227 . 2005 . 15595731 . 10.1021/pr0498887 . vanc. Busby SA . Barber CM . 3 . Shabanowitz . Jeffrey . Allis . C. David . Hunt . Donald F. .
• Andersen JS . Nucleolar proteome dynamics . Nature . 433 . 7021 . 77–83 . 2005 . 15635413 . 10.1038/nature03207 . vanc. Lam YW . Leung AK . 3 . Ong . Shao-En . Lyon . Carol E. . Lamond . Angus I. . Mann . Matthias . 2005Natur.433...77A . 4344740 .
• Happel N, Schulze E, Doenecke D . Characterisation of human histone H1x . Biol. Chem. . 386 . 6 . 541–551 . 2005 . 16006241 . 10.1515/BC.2005.064 . 39956199 .
• Olsen JV . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–648 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . vanc. Blagoev B . Gnad F . 3 . Macek . Boris . Kumar . Chanchal . Mortensen . Peter . Mann . Matthias . 7827573 . free.
• Takata H . H1.X with different properties from other linker histones is required for mitotic progression . FEBS Lett. . 581 . 20 . 3783–3788 . 2007 . 17632103 . 10.1016/j.febslet.2007.06.076 . vanc. Matsunaga S . Morimoto A . 3 . Onomaniwa . R . Uchiyama . S . Fukui . K . 45800557 . free.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Histone H1x

Notes and References

1. Yamamoto T, Horikoshi M . Cloning of the cDNA encoding a novel subtype of histone H1 . Gene . 173 . 2 . 281–285 . Dec 1996 . 8964515 . 10.1016/0378-1119(96)00020-0 .
2. Albig W, Doenecke D . The human histone gene cluster at the D6S105 locus . Hum Genet . 101 . 3 . 284–294 . Feb 1998 . 9439656 . 10.1007/s004390050630 . 38539096 .
3. Web site: Entrez Gene: H1FX H1 histone family, member X.