H1FNT explained
H1 histone family, member N, testis-specific |
Hgncid: | 24893 |
Symbol: | H1FNT |
Altsymbols: | HANP1, H1T2 |
Entrezgene: | 341567 |
Refseq: | NM_181788 |
Uniprot: | Q75WM6 |
Chromosome: | 12 |
Arm: | q |
Band: | 13.11 |
H1 histone family, member N, testis-specific is a member of the histone family of nuclear proteins which are a component of chromatin. In humans, this protein is encoded by the H1FNT gene.[1]
The H1FNT protein is essential for nuclear formation in spermatozoa, and is involved in the replacement of histones with protamines during spermiogenesis.[2]
Notes and References
- Martianov I, Brancorsini S, Catena R, etal . Polar nuclear localization of H1T2, a histone H1 variant, required for spermatid elongation and DNA condensation during spermiogenesis . Proceedings of the National Academy of Sciences of the United States of America . 102 . 8 . 2808–13 . February 2005 . 15710904 . 549447 . 10.1073/pnas.0406060102 . 2005PNAS..102.2808M . free .
- Tanaka H, Matsuoka Y, Onishi M, Kitamura K, Miyagawa Y, Nishimura H, Tsujimura A, Okuyama A, Nishimune Y . Expression profiles and single-nucleotide polymorphism analysis of human HANP1/H1T2 encoding a histone H1-like protein . International Journal of Andrology . 29 . 2 . 353–9 . April 2006 . 16533358 . 10.1111/j.1365-2605.2005.00600.x . free .